Office of Science
FAQ
Capabilities

NMR Spectrometer: 600-MHz NB Varian Inova - Cryoprobe (Liquids) - (Baker)

Quick Specs

  • 600 MHz 1H frequency
  • VNMRS DirectDrive-2 (DD2) console
  • VnmrJ 3.1 software
  • HCN cold probe

Highlighted Research Applications

Researchers may operate the system independently and can be trained to manage fully self-directed operations. Collaborative work with staff scientists is encouraged. For remote use, the user may ship sample(s) to EMSL, and a staff scientist will assist with placing the sample(s) in the magnet and tuning the probe. The user can then operate the spectrometer via a secure Internet connection.

Solution-state probes:

The spectrometer is equipped with four radio frequency channels and a Z-axis gradient amplifier.

  1. Mixed-Isotope Labeling with LC-IMS-MS for Characterization of Protein-Protein Interactions by Chemical Cross-Linking .
  2. High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field .
  3. A multi-omic systems approach to elucidating Yersinia virulence mechanisms.
  4. Combining Functional and Structural Genomics to Sample the Essential Burkholderia Structome.
  5. Chemical shift assignments for Rv0577, a putative glyoxylase associated with virulence from Mycobacterium tuberculosis .
  1. Biochemical studies provide insight into an RNA silencing pathway (The great repression)