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Mass spectrometry offers new clues to treat dengue infection

Excerpt from the open-access journal PLoS Pathogens news story, Research points to possible new route to fight dengue virus

Researchers have identified enzymes and biochemical compounds called lipids that are targeted and modified by the dengue virus during infection, suggesting a potential new approach to control the aggressive mosquito-borne pathogen. Their results appear March 22nd in the Open Access Journal PLoS Pathogens.

Findings also suggest that medications used to treat high cholesterol and other lipid-related conditions might also inhibit dengue's replication and could represent a potential new therapy. The researchers have identified how infected mosquito cells undergo changes to certain lipids in membranes and in biochemical sensors that alert cells of invading viruses.

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EMSL’s high-performance liquid chromatography-mass spectrometry capability played a key role in the analysis of dengue-infected mosquito cells and revealed that membrane remodeling is directly linked to a unique lipid repertoire induced by dengue virus infection.

Learn more by reading the related Purdue University news item.

Reference: Perera R, C Riley, G Isaac, AS Hopf-Jannasch, RJ Moore, KW Weitz, L Pasa-Tolic, TO Metz, J Adamec, RJ Kuhn. 2012. “Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells.” PLoS Pathogens 8(3):e1002584. doi:10.1371/journal.ppat.1002584.

Released: March 28, 2012