Skip to main content

Robert Young
Chemist

Dr. Robert Young is a chemist in the Biomolecular Pathways team. With more than 12 years of experience as a nuclear magnetic resonance (NMR) spectroscopist, Young has been involved a wide array of applications from biological to synthetic materials chemistry.

Research Interests

NMR applications in biological and environmental chemistry

Education

  • PhD in Chemistry, University of California, Riverside, 2016
  • BS in Chemistry, University of California, Riverside, 2010

Awards and Recognition

Fellow, National Science Foundation Graduate Research Fellowship Program 2011 – 2014)

Publications

2020

Warneke J., M. Mayer, M. Rohdenburg, X. Ma, J.K. Liu, M. Grellmann, and S. Debnath, et al. 2020 “Direct functionalization of C-H bonds by electrophilic anions.” Proceedings of the National Academy of Sciences of the United States of America, 117, no. 38:23374-23379. PNNL-SA-149918. doi:10.1073/pnas.2004432117

Chen Y., N.R. Jaegers, K. Han, H. Wang, R.P. Young, G. Agarwal, and A.S. Lipton, et al. 2020 “Probing Conformational Evolution and Associated Dynamics of Mg(N(SO2CF3)2)2 Dimethoxyethane Adduct Using Solid-state 19F and 1H NMR.” Journal of Physical Chemistry C 124, no. 9:4999-5008. PNNL-SA-148880. doi:10.1021/acs.jpcc.9b10212

Huang X., Q. Zhao, R.P. Young, X. Zhang, E.D. Walter, Y. Chen, and E. Nakouzi, et al. 2020. "Photo-production of Reactive Oxygen Species and Degradation of Dissolved Organic Matter by Hematite Nanoplates Functionalized by Adsorbed Oxalate." Environmental Science: Nano 7, no. 8:2278-2292. PNNL-SA-148918. doi:10.1039/D0EN00365D

Meng Q., S. Moinuddin, S. Kim, D.L. Bedgar, M.A. Costa, D.G. Thomas, and R.P. Young, et al. 2020. "Pterocarpan synthase (PTS) structures suggest a common quinone methide-stabilizing function in dirigent proteins and proteins with dirigent-like domains." Journal of Biological Chemistry 295, no. 33:11584-11601. PNNL-SA-150677. doi:10.1074/jbc.RA120.012444

2019

Chen Y., N.M. Washton, R.P. Young, A.J. Karkamkar, J.J. De Yoreo, and K.T. Mueller. 2019. "Monitoring solvent dynamics and ion associations in the formation of cubic octamer polyanion in tetramethylammonium silicate solutions." Physical Chemistry Chemical Physics. PCCP 21, no. 9:4717-4720. PNNL-SA-141469. doi:10.1039/C8CP07521B

Garcellano R.C., S. Moinuddin, R.P. Young, M.E. Bowden, M. Zhou, R.S. Renslow, and Y. Yesiltepe, et al. 2019. "Isolation of Tryptanthrin and Reassessment of Evidence for its Isobaric Isostere Wrightiadione in Plants of the Wrightia Genus." Journal of Natural Products 82, no. 3:440-448. PNNL-SA-135279. doi:10.1021/acs.jnatprod.8b00567

Green A.R., K. Li, B. Lockard, R.P. Young, L.J. Mueller, and C.K. Larive. 2019. "Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides." Journal of Physical Chemistry B 123, no. 22:4653-4662. PNNL-SA-144338. doi:10.1021/acs.jpcb.9b01794

Young, R. P., C. R. Lewis, C. Yang, L. Wang, J. K. Harper, and L. J. Mueller. 2019. “Tensorview: A Software Tool for Displaying NMR Tensors.” Magnetic Resonance in Chemistry 57 (5): 211-223. doi.org/10.1002/mrc.4793. 

2018

Sun J., D. Liu, R.P. Young, A.G. Cruz, N.G. Isern, T. Schuerg, and J.R. Cort, et al. 2018. "Solubilization and Upgrading of High Polyethylene Terephthalate Loadings in a Low-Costing Bifunctional Ionic Liquid." ChemSusChem 11, no. 4:781-792. PNNL-SA-128561. doi:10.1002/cssc.201701798

Warneke J., M.E. McBriarty, S.L. Riechers, S. China, M.H. Engelhard, E. Apra, and R.P. Young, et al. 2018. "Self-organizing layers from complex molecular anions." Nature Communications 9, no. 1:1889. PNNL-SA-128240. doi:10.1038/s41467-018-04228-2

2017

Soss, S. E., P. F. Flynn, R. J. Iuliucci, R. P. Young, L. J. Mueller, J. Hartman, G. J. O. Beran, and J. K. Harper. 2017. “Measuring and Modeling Highly Accurate 15N Chemical Shift Tensors in a Peptide.” ChemPhysChem 18 (16): 2225-2232. doi.org/10.1002/cphc.201700357.

2016

Caulkins, B. G., R. P. Young, R. A. Kudla, C. Yang, T. J. Bittbauer, B. Bastin, E. Hilario, L. Fan, M. J. Marsella, M. F. Dunn, and L. J. Mueller. 2016. “NMR Crystallography of a Carbanionic Intermediate in Tryptophan Synthase: Chemical Structure, Tautomerization, and Reaction Specificity.” Journal of the American Chemical Society 138 (46): 15214-15226. doi.org/10.1021/jacs.6b08937.

Young, R. P., B. G. Caulkins, D. Borchardt, D. N. Bulloch, C. K. Larive, M. F. Dunn, and L. J. Mueller. 2016. “Solution-State 17O Quadrupole Central-Transition NMR Spectroscopy in the Active Site of Tryptophan Synthase.” Angewandte Chemie - International Edition 55 (4): 1350-1354. doi.org/10.1002/anie.201508898.

Beecher, C. N., R. P. Young, D. J. Langeslay, L. J. Mueller, and C. K. Larive. 2014. “Hydroxyl-Proton Hydrogen Bonding in the Heparin Oligosaccharide Arixtra in Aqueous Solution.” Journal of Physical Chemistry B 118 (2): 482-491. doi.org/10.1021/jp410540d.  

Caulkins, B. G., B. Bastin, C. Yang, T. J. Neubauer, R. P. Young, E. Hilario, Y. M. M. Huang, C. E. A. Chang, L. Fan, M. F. Dunn, M. J. Marsella, and L. J. Mueller. 2014. “Protonation States of the Tryptophan Synthase Internal Aldimine Active Site from Solid-State NMR Spectroscopy: Direct Observation of the Protonated Schiff Base Linkage to Pyridoxal-5′-Phosphate.” Journal of the American Chemical Society 136 (37): 12824-12827. doi.org/10.1021/ja506267d.  

Langeslay, D. J., R. P. Young, S. Beni, C. N. Beecher, L. J. Mueller, and C. K. Larive. 2012. “Sulfamate Proton Solvent Exchange in Heparin Oligosaccharides: Evidence for a Persistent Hydrogen Bond in the Antithrombin-Binding Pentasaccharide Arixtra.” Glycobiology 22 (9): 1173-1182. doi.org/10.1093/glycob/cws085.