Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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A multi-pronged approach to characterizing amelogenin’s role in enamel formation

Date: 
Monday, November 4, 2019
Principal Investigator: 
Garry Buchko
Lead Institution: 
Pacific Northwest National Laboratory
Closed Date: 
Wednesday, September 30, 2020
Project ID: 
51215
Abstract: 

Biomineralization is the process used by living organism to produce minerals with properties not always found in their equivalent inorganically produced counterparts. In vertebrates, mineralized tissues such as bone, cementum, dentin and enamel all consist of calcium phosphate, but have specialized functions as a result of the conditions during formation. Biomineralization proteins are an essential contributor to the resulting materials properties, as they orchestrate the nucleation, growth, and organization of biominerals. Understanding the fundamental mechanisms responsible for this orchestration is important because this knowledge will guide the design of advanced materials in general and new repair or regeneration strategies for biominerals.