Environmental Molecular Sciences Laboratory

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Patents

Patent documentation is available at the United States Patent and Trademark Office.

2020

  • Walter, Eric; Sears, Jesse; Mehta, Hardeep; Hoyt, David. February 2020. “Snap-In Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy.” U.S. Patent 10,550,889

2019

  • Zhu, Zihua and Wang, Chongmin. December 2019. “Battery Cell and In-Situ Battery Electrode Analysis Method.” U.S. Patent 10,505,234
  • Kovarik, Libor; Stevens, Andrew J.; Liyu, Andrey V.; Browning, Nigel D. October 2019. “Sparse Sampling Methods and Probe Systems for Analytical Instruments.” U.S. Patent 10,431,419
  • Yu, Xiao-Ying; Liu, Bingwen; Yang, Li; Zhu, Zihua; Marshall, Matthew J. June 2019. “Microfluidic Electrochemical Device and Process for Chemical Imaging and Electrochemical Analysis at the Electrode-Liquid Interface In-Situ.” U.S. Patent 10,330,626
  • Barinaga, Charles; Carado, Anthony; Koppenaal, David; Marcus, Kenneth; Quarles, Charles Jr; Russo, Richard. April 2019. "Means of Introducing an Analyte into Liquid Sampling Atmospheric Pressure Glow Discharge." U.S. Patent 10,269,525
  • Stevens, Andrew; Kovarik, Libor; Liyu, Andrey; Browning; Nigel. April 2019. "Optimized Sub-Sampling in an Electron Microscope.” U.S. Patent 10,256,072
  • Stevens, Andrew; Kovarik, Libor; Browning, Nigel; Liyu, Andrey; Yuan, Xin; Carin, Lawrence. March 2019. “Compressive Transmission Microscopy.” U.S. Patent 10,224,175
  • Zheng, Jianming; Zhang, Jiguang; Yan, Pengfei; Wang, Chongmin; Zhao, Wengao; Chen, Shuru; Xu, Wu. March 2019. “High Capacity and Stable Cathode Materials.” U.S. Patent 10,243,206
  • Browning, Nigel; Kovarik, Libor; Stevens, Andrew. January 2019. “TEM Phase Contrast Imaging with Image Plane Phase Grating.” U.S. Patent 10,170,274

2018

  • Beliaev, Alex S; Bernstein, Hans C; Jansson, Georg Christer; Lindemann, Stephen R; McClure, Ryan S. November 2018. “Microbial Consortia for Programmable Output Via Photoautotroph-Heterotroph Interactions.” U.S. Patent 10,125,348
  • Laskin,Julia; Liyu,Andrey V; Nguyen, Son N. November 2018. “Techniques for Controlling Distance Between a Sample and Sample Probe While Such Probe Liberates Analyte from a Sample Region for Analysis with a Mass Spectrometer.” U.S. Patent 10,134,572
  • Browning, Nigel; Kovarik, Libor; Liyu, Andrey; Stevens, Andrew. October 2018. “Electron Beam Masks for Compressive Sensors.” U.S. Patent 10,109,453
  • Alexander, Mikaela; Blake, Thomas; Kelly, James; Moran, James; Newburn, Matthew; Sams, Robert. April 2018. “Capillary Absorption Spectrometer and Process for Isotopic Analysis of Small Samples.” U.S. Patent 9,952,144
  • Dai, Ziyu; Baker, Scott. March 2018. "Enhanced itaconic acid production in Aspergillus with increased LaeA expression." U.S. Patent 9,909,152
  • Laskin, Alexander; Laskin,Julia; Roach,Patrick J January 2018. "Focused Analyte Spray Emission Appratus and Process for Mass Spectrometric Analysis." U.S. Patent Canada Patent 2791047

2017

  • Hoyt, D; Hu, J; Sears, J; Rosso, K; Turcu, R., December 2017. “Devices and Process for High-Pressure Magic Angle Spinning Nuclear Magnetic Resonance.” U.S. Patent 9,835,698
  • Kelly, Ryan; Page, Jason; Smith, Richard; Tang, Kegi. November 2017. "Low Pressure Electrospray Ionization System and Process for Effective Transmission of Ions." U.S. Patent Canada Patent 2696115
  • Kelly, Ryan; Page, Jason; Smith, Richard; Tang, Kegi. September 2017. "Low Pressure Electrospray Ionization System and Process for Effective Transmission of Ions." U.S. Patent 2,700,092
  • Barinaga, Charles; Carado, Anthony; Koppenaal, David; Marcus, Kenneth; Quarles, Charels Jr; Russo, Richard. January 2017. "Means of introducing an analyte into liquid sampling atmospheric pressure glow discharge." U.S. Patent 9,536,725

2016

  • Cho, Herman; Washton, Nancy; Mueller, Karl; Sears, Jesse; Townsend, Mark; Ewing, James. June 2016. "Sealed magic angle spinning nuclear magnetic resonance probe and process for spectroscopy of hazardous samples." U.S. Patent 366736 B2
  • Yu, Xiao-Ying; Oiu, Bingwen; Yang, Li; Zhu, Zihua; Marshall, Matthew. March 2016. "Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ." U.S. Patent 9274059 B2

2015

  • Hoyt, David, Hu Jian, Mehta, Hardeep S, Peden, Charles HF, Sears Jesse. November 2015. “Magic Angle Spinning Nuclear Magnetic Resonance Apparatus and Process for High-Resolution in Situ Investigation.” U.S. Patent 9,194,920
  • Feng,Ju (PF313); Hu,Jian Z (PW333); Mehta,Hardeep S (PW413). June 2015. “Slow Magic Angle Spinning Nuclear Magnetic Resonance Device and Process for Metabolomics Profiling of Tissues and Biofluids.” U.S. Patent 9,063,196
  • Baker, Scott; Dai, Ziyu. May 2015." Enhanced Citric Acid Production in Aspergillus with Inactivated Asparagine-Linked Glycosylation Protein 3 (ALG3) and/or increased LAEA Expression." U.S. Patent 9,023,637

2014

  • Hoyt, David W; Hu, Jian Z; Rosso, Kevin M; Sears Jr, Jesse A; Turcu, Romulus VF. April 2014. "Devices and Processes for High-Pressure Magic Angle Spinning Nuclear Magnetic Resonance." U.S. Patent 8,692,548
  • Barinaga, Charles J; Koppenaal, David W. February 2014. "Combined Distance-of-Flights and Time-of-Flight Mass Spectrometer." U.S. Patent U.S. Patent 8,648,295

2013

  • Cowin, James P; Iedema,Martin J; Yang, Li; Yu,Xiao-Ying; Zhu,Zihua. October 2013. "Systems and Methods for Analyzing Liquids Under Vacuum." U.S. Patent 8,555,710

2012

  • Kelly, Ryan T; Smith, Richard D; Sun, Xuefei; Tang, Keqi. October 2012. "Microchip Capillary Electrophoresis Absent Electrokinetic Injection." U.S. Patent 8,277,659
  • Kelly, Ryan T; Page, Jason S; Smith, Richard D; Tang,Keqi. May 2012. "Low Pressure Electrospray Ionization System and Process for Effective Transmission of Ions." U.S. Patent 8,173,960
  • Holmtom, Gary R. March 2012. "Mode-Locked Solid State Lasers Using Diode Laser Excitation." U.S. Patent 8,130,800
  • Laskin, Alexander; Laskin, Julia, Roach, Patrick. January 2012. "Focused Analyte Spray Emission Appratus and Process for Mass Spectrometric Analysis." U.S. Patent 8,097,845

2011

  • Kelly, Ryan T; Page, Jason S; Smith, Richard D; Tang,Keqi. November 2011. "Lossless Droplet Transfer for Droplet-based Microfluidic Analysis." U.S. Patent 8,061,187
  • Kelly, Ryan T; Page, Jason S; Smith, Richard D; Tang,Keqi. November 2011. "Lossless Droplet Transfer for Droplet-based Microfluidic Analysis." U.S. Patent 8,061,187

2010

  • Kelly,Ryan T; Smith,Richard D; Tang,Keqi. October 2010. "Radiial Arrays of Nano-Electrospray Ionization Emitters and Methods of Forming Electrosprays." U.S. Patent 7,816,645
  • Baker,Eddie G; Gao,Yufei; Tonkovich,Anna Lee Y; VanderWiel,David P; Wang,Yong. April 2010. "Catalyst Structure and Method Of Fischer-Tropsch Synthesis." U.S. Patent 7,700,518
  • Kelly,Ryan T; Page,Jason S; Smith,Richard D; Tang,Keqi. March 2010. "Low Pressure Electrospray Ionization System and Process for Effective Transmission of Ions." U.S. Patent 7,671,344

2009

  • Baker,Eddie G; Gao,Yufei; Tonkovich,Anna Lee Y; VanderWiel,David P; Wang,Yong. September 2009. "Catalyst Structure and Method Of Fischer-Tropsch Sythesis." U.S. Patent 7,585,899
  • Hoyt,David W; Hu,Jian Z; Sears Jr,Jesse A; Wind,Robert A. May 2009. "Discrete Magic Angle Turning System, Apparatus, and Process for In Situ Magnetic Resonance Spectroscopy and Imaging." U.S. Patent 7,535,224
  • Gao,Yufei; Tonkovich,Anna Lee Y; Wang,Yong. March 2009. "Catalyst, Method of Making, and Reactions Using the Catalyst." U.S. Patent 7,498,001
  • Kelly,Ryan T; Page,Jason S; Smith,Richard D; Tang,Keqi. February 2009. "Method of Making Tapered Capillary Tips with Constant Inner Diameters." U.S. Patent 7,491,341

2008

  • Shvartsburg AA, RD Smith, and GA Anderson. November 2008. "Method and Apparatus for High-order Differential Mobility Separations." U.S. Patent 7,449,683

2007

  • Anderson, GA, KJ Auberry, LJ Kangas, and RD Smith. November 2006. "Method for Enhanced Accuracy in Predicting Peptides using Liquid Separations or Chromatography." U.S. Patent 7,136,759
  • Gilbert RW, CL Carrender, GA Anderson, and KD Steele. February 2007. "Multi-Mode Radio Frequency Device." U.S. Patent 7,176,784

2006

  • Amonette JE, Autrey ST, Foster-Mills NS. February 2006. "Photoacoustic spectroscopy sample array vessels and photoacoustic spectroscopy methods for using the same." U.S. Patent 6,999,174
  • Wind; RA, Hu, JZ, Minard, KR, Rommereim, DN. January 2006. "Advanced slow-magic angle spinning probe for magnetic resonance imaging and spectroscopy." U.S. Patent 6,989,674

2005

  • Tang; K, Belov, MB, Tolmachev, AV, Udseth; HR, Smith, RD. December 2005. "Multi-source ion funnel." U.S. Patent 6,979,816
  • Hess WP, Joly AG, Gerrity DP, Beck KM, Sushko PV, Shlyuger AL. June 2005. "Particle generator." U.S. Patent 6,911,649
  • Amonette JE, Autrey ST, Foster-Mills NS, Green D. March 2005. "Photoacoustic spectroscopy sample array vessel and photoacoustic spectroscopy method for using the same." U.S. Patent 6,873,415
  • Weller RE, Lind MA, Fisher DR, Gutowska A, Campbell AA. March 2005. "Stimulus sensitive gel with radioisotope and methods of making." U.S. Patent 6,869,588

2004

  • Tonkyn RG, Barlow SE, Balmer ML, Maupin GD. October 2004. "NOx reduction methods and apparatuses." U.S. Patent 6,808,694
  • Belov M, Smith RD, Udseth HR. September 2004. "Method for increasing the dynamic range of mass spectrometers." U.S. Patent 6,787,760
  • Steele KD, Anderson GA, Gilbert RW. July 2004. "Multi-level RF identification system." U.S. Patent 6,765,476
  • Wang Y, Vanderwiel DP, Tonkovich AY, Gao Y, Baker EG. June 2004. "Catalyst structure and method of Fischer-Tropsch synthesis." U.S. Patent 6,750,258
  • Elder SH, Su Y, Gao Y, Heald SM. February 2004. "Nanocrystalline Heterojunction Materials." U.S. Patent 6,685,909
  • Beck KM, Wunschel DS. January 2004. "High spatial resolution matrix assisted laser desorption/ionization (MALDI)." U.S. Patent 6,680,477

2003

  • Wang Y, Vanderwiel DP, Tonkovich AY, Gao Y, Baker EG. December 2003. "Catalyst structure and method of Fischer-Tropsch synthesis." U.S. Patent 6,660,237
  • Tonkovich A, Wang Y, Wegeng RS, Gao Y. September 2003. "Method and apparatus for obtaining enhanced production rate of thermal chemical reactions." U.S. Patent 6,616,909
  • Grate J, Wise B. August 2003. "Methods for characterizing, classifying, and identifying unknowns in samples." U.S. Patent 6,606,567
  • Elder SH, Su Y, Gao Y, Heald SM. July 2003. "Nanocrystalline Heterojunction Materials." U.S. Patent 6,592,842
  • Smith RD, Kim T, Tang K, and Udseth HR. June 2003 "Ionization Source Utilizing a Jet Disturber in Combination with an Ion Funnel and Method of Operation." U.S. Patent 6,583,408
  • Wang Y, Vanderwiel DP, Tonkovich AY, Gao Y, Baker EG. May 2003. "Catalyst structure and method of fischer-tropsch synthesis." U.S. Patent 6,558,634
  • Tonkovich A, Wang Y, Wegeng RS, Gao Y. April 2003. "Method and apparatus for obtaining enhanced production rate of thermal chemical reactions." U.S. Patent 6,540,975
  • Liang Y, Daschbach JL, Su Y, Chambers SA. March 2003. "Structure having spatially separated photo-excitable electron-hole pairs and method of manufacturing same." U.S. Patent 6,534,782
  • Chandler DP, Posakony GJ, Bond LJ, Bruckner-Lea CJ. January 2003. "Apparatus and method for ultrasonic treatment of a liquid." U.S. Patent 6,506,584

2002

  • Anderson GA, Brands MD, Bruce JE, Pasa-Tolic L, Smith RD. December 2002. "Method for calibrating mass spectrometers." U.S. Patent 6,498,340
  • Wang Y, Vanderwiel DP, Tonkovich AY, Gao Y, Baker EG. December 2002. "Catalyst structure and method of fischer-tropsch synthesis." U.S. Patent 6,491,880
  • Tonkovich A, Wang Y, Gao Y. November 2002. "Long life hydrocarbon conversion catalyst and method of making." U.S. Patent 6,479,428
  • Wang Y, Vanderwiel DP, Tonkovich AY, Gao Y, Baker EG. September 2002. "Catalyst structure and method of Fischer-Tropsch synthesis." U.S. Patent 6,451,864
  • Gao Y, Tonkovich A, Wang Y. August 2002. "Catalyst, Method of Making, and Reactions Using the Catalyst." U.S. Patent 6,440,895
  • Armstrong B, Campbell AA, Gutowska A, Song L. July 2002. "Polymer/Ceramic Composites*." U.S. Patent 6,417,247
  • Grate J, Wise B. June 2002. "Methods For Characterizing, Classifying, And Identifying Unknowns In Samples." U.S. Patent 6,408,250
  • Gao Y, Liu J. March 2002. "Carbon Nanotubes On A Substrate" U.S. Patent 6,361,861
  • Amonette J, Autrey ST, Daschbach J, Foster-Mills N. February 2002. "Photoacoustic Spectroscopy Apparatus and Method." U.S. Patent 6,348,968

2001

  • Fulton JL, Hoffmann MM. November 2001. "Rare Earth Oxide Fluoride Nanoparticles and Hydrothermal Method For Forming Nanoparticles." U.S. Patent 6,316,377
  • Weller RE, Lind MA, Fisher DR, Gutowska A, Campbell AA. October 2001. "Stimulus Sensitive Gel with Radioisotope And Methods Of Making." U.S. Patent 6,296,831
  • Wang Y, VanderWiel DP, Tonkovich AY. September 2001. "Method and Catalyst Structure for Steam Reforming of a Hydrocarbon" U.S. Patent 6,284,217
  • Eiden GC, Barinaga CJ, Koppenaal DW. July 2001. "An Apparatus for Reduction of Selected Ion Intensities in Confined Ion Beams." U.S. Patent 6,259,091
  • Phelps MR, Yonker CR, Fulton JL, Bowman LE. July 2001. "A Method of Filtering a Target Compound From a First Solvent That is Above Its Critical Density." U.S. Patent 6,264,726
  • Autrey ST, Posakony GJ, Amonette JE, Foster-Mills NS. June 2001. "Photoacoustic Method for Measuring Concentration of Chemical Species." U.S. Patent 6,244,101
  • Autrey ST, Daschbach JL, Amonette JE, Foster-Mills NS. May 2001. "Photoacoustic Spectroscopy Sample Cells and Methods of Photoacoustic Spectroscopy." U.S. Patent 6,236,455
  • Smith RD, Liu C. February 2001. "Apparatus for Molecular Weight Separation." U.S. Patent 6,187,190

2000

  • Holman DA, Grate JW, Bruckner-Lea CJ. December 2000. "Apparatus and Method for Handling Magnetic Particles in a Fluid." U.S. Patent 6,159,378
  • Egorov OB, Grate JW, Bray LA. November 2000. "Method for Sequential Injection of Liquid Samples for Radioisotope Separations." U.S. Patent 6,153,154
  • Egorov OB, O'Hara MJ, Grate JW, Chandler DP, Brockman FJ, Bruckner-Lea CJ. October 2000. "Systems for Column-Based Separations, Methods of Forming Packed Columns, and Methods of Purifying Sample Components." U.S. Patent 6,136,197
  • Gao Y, Campbell AA. September 2000. "Method of Coating a Substrate with a Calcium Phosphate Compound," U.S. Patent 6,113,993
  • Holtom GR, Xie XS, Zumbusch A. August 2000. "Nonlinear Vibrational Microscopy." U.S. Patent 6,108,081
  • Smith RD, Shaffer SA. August 2000. "Method and Apparatus for Directing Ions and Other Charged Particles Generated at Near Atmospheric Pressures Into a Region Under Vacuum." U.S. Patent 6,107,628
  • Tanner DD, Ding Q, Kandanarachchi P, Franz JA. August 2000. "Method of Microwave Bond Cleavage of a Hydrocarbon Compounding a Liquid Phase." U.S. Patent 6,106,675
  • Brewster ME, Miller NE. May 2000. "Information Retrieval System Utilizing Wavelet Transform." U.S. Patent 6,070,133
  • Grate JW, Kaganove SN. January 2000. "Strongly Hydrogen-Bond Acidic Polymer and Methods of Making and Using." U.S. Patent 6,015,869

1999

  • Smith RD, Severs JC. November 1999. "Capillary Electrophoresis Electrospray Ionization Mass Spectrometry Interface." U.S. Patent 5,993,633
  • Sharma AK, Camaioni DM, Josephson GB. November 1999 "Corona Method and Apparatus for Altering Carbon Containing Compounds." U.S. Patent 5,980,701
  • Campbell AA, Song L. September 1999. "Thin Film Composition with Biological Substance and Method of Making." U.S. Patent 5,958,430
  • Smith RD, Liu C. September 1999. "Microdialysis Unit for Molecular Weight Separation." U.S. Patent 5,954,959
  • Peurrung AJ, Barlow SE. August 1999. "Method and Apparatus for Confinement of Ions in the Presence of a Neutral Gas." U.S. Patent 5,931,986
  • Barlow SE, Orlando TM, Tonkyn RG. June 1999. "Method and Apparatus for Processing Exhaust Gas with Corona Discharge." U.S. Patent 5,914,015
  • Bowman LE. May 1999. "Method for Removing Organic Coatings from Substrates." U.S. Patent 5,904,155
  • Fulton JL, Yonker CR, Hallen RR, Baker EG, Bowman LE, Silva LJ. January 1999. "Method for Sizing and Desizing Yarns with Liquid and Supercritical Carbon Dioxide Solvent." U.S. Patent 5,863,298

1998

  • Janata J, McVay GL, Peden CH, Exarhos GJ. July 1998. "Apparatus for Photocatalytic Destruction of Internal Combustion Engine Emissions During Cold Start." U.S. Patent 5,778,664
  • Camaioni DM, Lilga MA. July 1998. "Method and Reaction Pathway for Selectively Oxidizing Hydrocarbon Compounds." U.S. Patent 5,786,505
  • Amonette JE, Fruchter JS, Gorby YA, Cole CR, Cantrell KJ, Kaplan DI. July 1998. "Method of Removing Oxidized Contaminants from Water." U.S. Patent 5,783,088
  • Linehan JC, Fulton JL, Bean RM. June 1998. "Process of Forming Compounds Using Reverse Micelle or Reverse Microemulsion Systems." U.S. Patent 5,770,172
  • Eiden GC, Barinaga CJ, Koppenaal DW. June 1998. "Method for Reduction of Selected Ion Intensities in Confined Ion Beams." U.S. Patent 5,767,512
  • Camaioni DM, Lilga MA. January 1998. "Method of Photocatalytic Conversion of C-H Organics." U.S. Patent 5,708,246

1997

  • Barlow SE, Alexander ML, Follansbee JC. December 1997. "Asymmetric Ion Trap." U.S. Patent 5,693,941
  • Matson DW, Fulton JL, Linehan JC, Bean RM, Brewer TD, Werpy TA, Darab JG. July 1997. "Catalyst Material and Method of Making." U.S. Patent 5,652,192
  • Balmer ML. January 1997. "Cesium Titanium Silicate and Method of Making." U.S. Patent 5,591,420

Technology transfer and collaboration with industry

EMSL works with industry and, via Pacific Northwest National Laboratory's technology commercialization office, offers its innovations for license. For more information, visit PNNL's Available Technologies website.

View a video (below) that shows how Agilent Technologies licensed and used the ion funnel developed in EMSL.