Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: University of Iowa
Principal Investigator: Kevin Campbell
The polymerization of matriglycan – a linear polysaccharide composed of alternating xylose and glucuronic acid units – on dystroglycan by LARGE1 is indispensable for neuromuscular function. Matriglycan anchors the cytoskeleton to the basement...
Lead Institution: University of Wisconsin, Madison
Principal Investigator: Deane Mosher
Eosinophils (EOS) are leukocytes that play roles in diseases marked by eosinophilic inflammation and processes of medical interest1,2. Crystalloid granules of EOS contain a payload of cytotoxic proteins unique to EOS. Upon activation with cytokines...
Lead Institution: University of Texas Southwestern Medical Center
Principal Investigator: Ryan Hibbs
The alpha7 nicotinic receptor is a broadly expressed pentameric ligand-gated ion channel found in the central nervous system as well as in the immune system and in epithelial cells. Here we propose to use a direct structural approach to understand...
Lead Institution: University of Iowa
Principal Investigator: Chou-Long Huang
a-Klotho is type-1 membrane protein of which mutation in mice results in phenotypes resembling premature human aging. Membranous a-klotho interacts with fibroblast growth factor receptor (FGFR) to form coreceptors for FGF23. The ectodomain of...
Lead Institution: University of Washington
Principal Investigator: Mengyu Wu
Protein assemblies with cage-like architectures are an emerging class of versatile nanoscale building blocks for a wide variety of applications including biological probes and delivery vehicles. However, it remains challenging to program their...
Lead Institution: Portland State University
Principal Investigator: Steve Reichow
Despite effective surgery, cataracts remain the leading cause of blindness worldwide – demanding our molecular-level understanding of this debilitating disease. Cataracts are a result of age- dependent chemical modifications to the major cytosolic...
Lead Institution: Oregon Health & Science University
Principal Investigator: Eric Gouaux
Signal transduction at the chemical synapses of the nervous system involves neurotransmitter release by presynaptic neurons into the synaptic cleft followed by activation of receptors, typically on the postsynaptic membrane. Glycine receptors (GlyR...
Lead Institution: Oregon Health & Science University
Principal Investigator: Liman Zhang
Nucleotide-binding domain and leucine rich repeat containing (NLR) proteins comprise a fascinating family that plays key roles in regulating immune signal transduction: they initiate inflammation in response to pathogens and danger signals by...
Lead Institution: Thomas Jefferson University
Principal Investigator: Erik Debler
The protozoan parasite Trypanosoma brucei causes fatal sleeping sickness in humans with 60 million people at risk. As an early-branching eukaryote, trypanosomes exhibit significant deviations in chromatin structure and gene regulation from most...
Lead Institution: University of California, San Francisco
Principal Investigator: Aashish Manglik
G protein-coupled receptors (GPCRs) are critically important regulators of human physiology and represent an outsized fraction of currently approved therapeutics. Over the past few years, cryo-EM of GPCRs has enabled structural interrogation of many...