Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Oregon Health & Science University
Principal Investigator: Liman Zhang
Nucleotide-binding domain and leucine rich repeat containing (NLR) proteins comprise a fascinating family that plays key roles in regulating immune signal transduction: they initiate inflammation in response to pathogens and danger signals by...
Lead Institution: Thomas Jefferson University
Principal Investigator: Erik Debler
The protozoan parasite Trypanosoma brucei causes fatal sleeping sickness in humans with 60 million people at risk. As an early-branching eukaryote, trypanosomes exhibit significant deviations in chromatin structure and gene regulation from most...
Lead Institution: University of California, San Francisco
Principal Investigator: Aashish Manglik
G protein-coupled receptors (GPCRs) are critically important regulators of human physiology and represent an outsized fraction of currently approved therapeutics. Over the past few years, cryo-EM of GPCRs has enabled structural interrogation of many...
Lead Institution: Duke University
Principal Investigator: Seok-Yong Lee
The transient receptor potential melastatin (TRPM) family of ion channels are the largest and most diverse group within the TRP channel superfamily. They are broadly distributed across various tissue and cell types and is involved in regulating...
Lead Institution: Duke University
Principal Investigator: Seok-Yong Lee
Calcium-permeable ion channels play crucial roles in cellular calcium signaling and thus many key physiological processes. Transient receptor potential (TRP) ion channels play major roles in sensory transduction. Recent studies have revealed that...
Lead Institution: University of British Columbia
Principal Investigator: Natalie Strynadka
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the first committed step in lipid biosynthesis in Bacteria and Eukarya. We aim to characterize AccM, an ACC from an oleaginous actinobacteria. We are pursuing the cryo-electron...
Lead Institution: Saint Louis University
Principal Investigator: Krishan Pandey
Integration of retroviral genome is mediated by viral integrase (IN) into host genome and is an essential step in retroviral replication. IN multimerizes on viral DNA to produce intasome and carry out catalytic steps. We are using cryo-EM to...
Lead Institution: Pennsylvania State University
Principal Investigator: Jean-Paul Armache
Many human diseases, such as cancer, neuropathies, and others result from DNA damage. Estimates suggest that an average human cell sustains tens of thousands of lesions each per day. With ~10^13 cells in the body, it is unthinkable for a complex...
Lead Institution: Oregon Health & Science University
Principal Investigator: Eric Gouaux
Ionotropic glutamate-receptor ion channels (iGluRs) are the major mediators of excitatory synaptic transmission that couple glutamate release to depolarization of postsynaptic neurons in the central nervous system. Among the cation permeable iGluRs...
Lead Institution: Reed College
Principal Investigator: Shivani Ahuja
The manganese transport regulator (MntR) of Bacillus subtilis has long been known to repress uptake of manganese by binding to its operator site and blocking access of RNA polymerase to the promoters controlling expression of manganese uptake...