Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Donald Danforth Plant Science Center
Principal Investigator: Dilip Shah
Antimicrobial peptides (AMPs) are a major component of innate immunity against infectious diseases in animals and plants [2]. A feature prominent in many families of AMPs, such as defensins (Figure 1), is disulfide covalent crosslinks between pairs...
Lead Institution: Pacific Northwest National Laboratory
Principal Investigator: Garry Buchko
Biomineralization is the process used by living organism to produce minerals with properties not always found in their equivalent inorganically produced counterparts. In vertebrates, mineralized tissues such as bone, cementum, dentin and enamel all...
Lead Institution: Pacific Northwest National Laboratory
Principal Investigator: Garry Buchko
A potential consequence of rapid climate change is the emergence of epidemic infectious zoonotic diseases as the habitats of disease carriers change to expose human populations to new infectious agents. These environmental changes, along with the...
Lead Institution: Washington State University
Principal Investigator: Norman Lewis
Our overall aim is to further identify, dissect, and exploit dirigent protein (DP) mediated supramolecular protein complexes for macromolecular lignin assembly in order to ultimately achieve facile biomass deconstruction. Our ongoing EMSL work has...
Lead Institution: Washington University in St. Louis
Principal Investigator: Marcus Foston
The last decade has witnessed the tremendous power of systems biology and multi-omics tools to characterize and understand complex biological systems, computational tools to integrate and leverage multi-omics datasets to improve systems-level...
Lead Institution: University of Massachusetts Amherst
Principal Investigator: Kristen DeAngelis
Climate change is a current crisis that requires reduced reliance on non-renewable fuels, and lignocellulose offers an abundant and undervalued renewable fuel alternative. Lignin is a strong barrier to the conversion of cellulose to biofuels, and...
Lead Institution: Pacific Northwest National Laboratory
Principal Investigator: Jason McDermott
The goal of this project is to attain a systems level understanding of the soil microbiome and its phenotypic response to changing moisture through a tractable, spatially explicit examination of the molecular and ecological interactions occurring...
Lead Institution: National Renewable Energy Laboratory
Principal Investigator: Davinia Salvachua Rodriguez
White rot fungi (WRF) are the most efficient organisms for the depolymerization and mineralization of lignin to CO2 and H2O in Nature and thus, WRF play a pivotal role in carbon cycling. Lignin depolymerization by WRF (extracellular process) has...