Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: University of Utah
Principal Investigator: Christopher Hill
Our goal is to determine the structure of heptameric AAA+ ATPase Bcs1 bound to its native substrate Rip1. Rip1 is a critical component of the Complex III of mitochondrial electron transport chain. To be incorporated into Complex III, Rip1 first...
Lead Institution: University of British Columbia
Principal Investigator: Natalie Strynadka
Wall teichoic acid (WTA) is a Gram-positive bacterial cell wall polymer with roles in host cell adherence and coordination of essential physiological processes including cell division and peptidoglycan synthesis. Importantly, the biogenesis of WTA...
Lead Institution: University of Nebraska - Lincoln
Principal Investigator: Alex Vecchio
Elongation of very long chain fatty acids (VLCFAs) in mammals is directed by membrane proteins called ELOngation of Very Long chain fatty acids (ELOVLs). ELOVLs catalyze the first and rate-limiting step in VLCFA elongation, and these VLCFAs confer...
Lead Institution: New York University School of Medicine
Principal Investigator: Da-Neng Wang
We will aim to determine the structures of two membrane transporters. (I) Na+-free form of the Na+-dependent dicarboxylate transporter VcINDY, a bacterial homolog of the human liver citrate transporter that is implicated in obesity. In the 2019 fall...
Lead Institution: Vanderbilt University Medical Center
Principal Investigator: Dana Lacy
Clostridioides difficile infection is often activated by alterations in the gut microbiota through antibiotic use, and recurrent infections are associated with severe clinical outcomes. Pathogenesis is mediated by the large clostridial toxins, and...
Lead Institution: Vanderbilt University
Principal Investigator: Hassane Mchaourab
The catalytic subunit of glucose-6-phosphatase, G6PC1, functions as a gatekeeper of glucose production in the liver by catalyzing the hydrolysis of glucose-6-phosphate. Dysregulation of G6PC1 gene expression contributes to elevated hepatic glucose...
Lead Institution: University of California, Riverside
Principal Investigator: Jikui Song
The eukaryotic genome is organized into different functional compartments, with euchromatin representing an open and transcriptionally active state and heterochromatin representing a more compact and silenced state. Notably, the state of...
Lead Institution: Memorial Sloan-Kettering Cancer Center
Principal Investigator: Stephen Long
The aims of this ongoing work are to determine 3D structures of ion channels involved in calcium signaling. These aims are central to our NIGMS R35 award GM13192, Mechanisms of Ion Channels in Calcium Signaling. The goal of the current proposal to...
Lead Institution: University of British Columbia
Principal Investigator: Calvin Yip
Post-translational modification of histone proteins is a key mechanism that eukaryotic cells use to regulate transcription. NuA4 and SAGA are two highly conserved histone aceyltransferase complexes that have served as key models for understanding...
Lead Institution: University of Toronto
Principal Investigator: Walid Houry
Cells have evolved various mechanisms for harnessing the energy from nucleotide hydrolysis and directing it towards useful work. One class of proteins using such a mechanism is the P-loop NTPases, which play critical roles in a vast array of...