Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Oregon State University
Principal Investigator: Stephen Giovannoni
Reports of ultra-small cell and streamlined genomes have flooded into the field of microbiology, providing support for the idea that the prevalence of streamlined bacteria in nature has been underestimated because they are challenging to culture....
Lead Institution: Washington State University
Principal Investigator: Norman Lewis
Our overall aim is to further identify, dissect, and exploit dirigent protein (DP) mediated supramolecular protein complexes for macromolecular lignin assembly in order to ultimately achieve facile biomass deconstruction. Our ongoing EMSL work has...
Lead Institution: University of California, Santa Barbara
Principal Investigator: Michelle O'Malley
We recently uncovered the biosynthetic machinery to produce a wide array of secondary metabolites within the genomes of the anaerobic fungal phylum Neocallimastigomycota. These fungi live among complex microbial consortia that degrade biomass within...
Lead Institution: Purdue University
Principal Investigator: Kevin Solomon
This project studies the impact of epigenetic regulation in anaerobic fungi to develop strategies that control lignocellulolytic enzyme expression and activity for increased lignocellulose breakdown. Anaerobic (gut) fungi are powerful digesters of...
Lead Institution: Washington University in St. Louis
Principal Investigator: Marcus Foston
The last decade has witnessed the tremendous power of systems biology and multi-omics tools to characterize and understand complex biological systems, computational tools to integrate and leverage multi-omics datasets to improve systems-level...
Lead Institution: University of Massachusetts Amherst
Principal Investigator: Kristen DeAngelis
Climate change is a current crisis that requires reduced reliance on non-renewable fuels, and lignocellulose offers an abundant and undervalued renewable fuel alternative. Lignin is a strong barrier to the conversion of cellulose to biofuels, and...
Lead Institution: Los Alamos National Laboratory
Principal Investigator: Ping Yang
The goal of this proposal is to characterize the molecular mechanisms associated to the a Mn2(II,II) core of the SoxB protein. This protein plays a central role in the sulfur oxidizing catalytic process used by bacteria to perform aerobic...
Lead Institution: Lawrence Livermore National Laboratory
Principal Investigator: Ty Samo
Attachment between phototrophic microalgae and heterotrophic bacteria is an integral yet understudied facet of microbial ecology. Such inter-kingdom cooperative partnerships have important consequences for biogeochemical cycling, ecosystem function...
Lead Institution: Pacific Northwest National Laboratory
Principal Investigator: Jason McDermott
The goal of this project is to attain a systems level understanding of the soil microbiome and its phenotypic response to changing moisture through a tractable, spatially explicit examination of the molecular and ecological interactions occurring...
Lead Institution: City College of New York
Principal Investigator: Michael Green
The properties of ion channel proteins, found in essentially all organisms, will be computed using quantum calculations. The principal techniques include optimization at Hartree-Fock level (determination of the structure of local energy minima) of...