Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Saint Louis University
Principal Investigator: Enrico Di Cera
The objective of this study, funded by 2 active NIH grants, is to elucidate the structures of key proteins and their interacting partners of the prothrombinase:prothrombin complex and the protein C anti-coagulant complex. This study addresses two...
Lead Institution: Oregon Health & Science University
Principal Investigator: Peter Barr-Gillespie
Hair cells are the sensory cells of the inner ear, and use the mechanically sensitive hair bundle to detect sound and head movements. Bundles are composed of a hundred or so stereocilia, each of which is constructed of several hundred parallel actin...
Lead Institution: University of Connecticut
Principal Investigator: Jianbin Ruan
Caspase-4/-5/-11 non-canonical inflammasomes have been known to play pivotal roles in various inflammatory and infectious diseases, such as sepsis. Current studies demonstrate that caspase-4/-5/-11 are activated by directly sensing the intracellular...
Lead Institution: Vanderbilt University
Principal Investigator: Erkan Karakas
Inositol 1,4,5-triphosphate receptors (IP3Rs) function as signaling hubs integrating diverse signals to regulate many physiological processes. Pathological dysregulation of IP3Rs and calcium signaling is implicated in cancer, neurodegenerative,...
Lead Institution: Fred Hutchinson Cancer Research Center
Principal Investigator: Barry Stoddard
Bacterial defense against phage infection is comprised of a large number of biological mechanisms and systems. A thorough understanding of such systems is crucial both for anti-bacterial phage therapy and for the use of microbial expression...
Lead Institution: University of British Columbia
Principal Investigator: Natalie Strynadka
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the first committed step in lipid biosynthesis in Bacteria and Eukarya. We aim to characterize AccM, an ACC from an oleaginous actinobacteria. We are pursuing the cryo-electron...
Lead Institution: University of Colorado Anschutz Medical Campus
Principal Investigator: Hongjin Zheng
Using siderophores to scavenge metal ions from the host is critical to the thrive of the bacteria during infections. The metal-chelated siderophores are reimported into the bacterial cells through a subgroup of ATP-binding cassette (ABC) importers....
Lead Institution: University of Texas Southwestern Medical Center
Principal Investigator: Jan Erzberger
We have genetically engineered yeast strain to trap distinct intermediates in the large ribosomal subunit maturation pathway. Single particle reconstructions of these particles reveal the function of large macromolecular complexes in regulating the...
Lead Institution: University of Michigan
Principal Investigator: Michael Cianfrocco
Kinesins represent a broad family of motor proteins responsible for diverse cellular activities ranging from axonal transport to mitotic spindle formation. Recently, a novel factor was discovered that inhibits kinesin motility along microtubules:...
Lead Institution: La Jolla Institute for Immunology
Principal Investigator: Kathryn Hastie
Machupo virus (MACV) was discovered in the 1960s and has remained endemic to Bolivia, causing several sporadic outbreaks of the highly lethal human disease, Bolivian Hemorrhagic Fever (BHF). No vaccines are approved for protection against BHF....