Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: California Institute of Technology
Principal Investigator: William Clemons
In the continuous race against bacterial infections, the development of new drugs becomes essential to find new ways to fight multidrug resistant bacteria. MraY catalyzes the first membrane step in the biosynthesis of peptidoglycan precursor lipid I...
Lead Institution: University of Texas Southwestern Medical Center
Principal Investigator: Ryan Hibbs
Our lab is focused on structural biology of ligand-gated ion channels; this project focuses specifically on high resolution structures of the native nicotinic acetylcholine receptor from the electric organ of the Torpedo ray. This acetylcholine...
Lead Institution: University of Colorado at Denver
Principal Investigator: Elan Eisenmesser
We propose completing the first complex of a bacterial IgA1 Protease (IgA1P) in complex with its human IgA1 substrate. Many opportunistic bacteria produce an IgA1P to cleave their human host IgA1 within its hinge region (Fig.1), the linker that...
Lead Institution: Northwestern University
Principal Investigator: Yuan He
Eukaryotic genomes are modulated by different types of chromatin remodeling complexes and transcribed by multiple RNA polymerases. Of the three polymerases, Pol I-III, that produce RNA required for protein production, key structural information for...
Lead Institution: ConfometRx, Inc.
Principal Investigator: Bingfa Sun
Our proposal establishes that the angiotensin type 2 receptor (AT2R) as a potential therapeutic target for COVID-19 pneumonia. There is a growing body of evidence that activation of AT2R reduces lung injury in acute respiratory distress syndrome, a...
Lead Institution: Fred Hutchinson Cancer Research Center
Principal Investigator: Marie Pancera
The ongoing global outbreak of atypical pneumonia (COVID-19) is caused by a newly emerged zoonotic beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1). On March 11th, 2020, the World Health Organization declared COVID-...
Lead Institution: La Jolla Institute for Immunology
Principal Investigator: Erica Saphire
Effective and rapid responses to the ongoing COVID-19 pandemic must involve vaccination, therapies and serology. Our laboratory has the required expertise to produce and manage significant volumes of survivor antibodies and SARS-CoV-2 proteins for...
Lead Institution: Boston Children's Hospital
Principal Investigator: Hao Wu
The outbreak of COVID-19 by SARS-CoV-2 infection has induced a global health crisis with millions of infections and about 20 thousand deaths. The replication of SARS-CoV-2 is dependent on RNA-dependent RNA polymerase (nsp12) and its cofactors of...
Lead Institution: University of California, San Diego
Principal Investigator: Gourisankar Ghosh
IKK complex serves as a central relay of signals from the membrane bound receptors, to regulate gene expression necessary for immune signaling and developmental processes. The ~270 kDa IKK complex contains kinases (IKK1 and/or IKK2) and a scaffold...
Lead Institution: The Scripps Research Institute
Principal Investigator: Andrew Ward
Rational vaccine design aims to focus antibody responses to vulnerable sites on the primary antigens. We used our recently developed electron microscopy polyclonal epitope mapping (EMPEM) approach to describe the antibody specificities elicited by...