Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Oregon Health & Science University
Principal Investigator: David Farrens
GPCRs are the largest family of membrane proteins in the human genome, and a major target of pharmaceutical drugs. However, relatively few GPCR structures are known. Moreover, many GPCRs are known to self-associate, yet few studies have reliably...
Lead Institution: Boston Children's Hospital
Principal Investigator: Hao Wu
The inflammatory response provides an absolutely essential host defense mechanism that, if perturbed, can itself cause a large number of human diseases. Collectively, innate immune responses integrate a number of genome-encoded sensor proteins to...
Lead Institution: University of Texas Southwestern Medical Center
Principal Investigator: Yuh Chook
Core histones organize DNA in the nucleus. Histones are synthesized in the cytoplasm and are be transported by to the nucleus by Karyopherin nuclear transport receptors. In the cytoplasm, histones also bind to histone chaperones, which often...
Lead Institution: University of Texas Southwestern Medical Center
Principal Investigator: Vincent Tagliabracci
Enzymes with a protein kinase fold transfer phosphate from ATP to substrates in a process known as phosphorylation. We have discovered that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein...
Lead Institution: Northwestern University
Principal Investigator: Amy Rosenzweig
Particulate methane monooxygenase (pMMO) is the primary enzyme used for methane metabolism by methane-consuming bacteria known as methanotrophs. pMMO is a copper-dependent, membrane-bound metalloenzyme that oxidizes methane to methanol by an unknown...
Lead Institution: Columbia University
Principal Investigator: Alexander Sobolevsky
Transient receptor potential (TRP) channels are polymodal sensory transducers that respond to chemicals, temperature, mechanical stress and membrane voltage and are involved in vision, taste, olfaction, hearing, touch, thermal perception and...
Lead Institution: Oregon Health & Science University
Principal Investigator: Liman Zhang
Class II transcription activator (CIITA) is immunologically critical for T cell maturation as it regulates the Major Histocompatibility Complex class II (MHC-II) gene expression. Unlike the other transcription factors, CIITA is recruited by the pre-...
Lead Institution: Fred Hutchinson Cancer Research Center
Principal Investigator: Betty Shen
The strategies employed by bacteria and archaea for combatting phage infection, and the corresponding ‘arms race’ between phage and their microbial targets, have generated a diverse arsenal of innate and adaptive systems for cellular defense and an...
Lead Institution: University of Michigan
Principal Investigator: Uhn-soo Cho
The FACT complex, composed of hSpt16 and SSRP1 in human, was initially discovered as a factor that is essential for transcription elongation. It functions as an ATP-independent histone chaperone to facilitate the disassembly and reassembly of...
Lead Institution: Yale University
Principal Investigator: Yong Xiong
Human immunodeficiency virus type 1 (HIV-1) infection is a global epidemic. Between the point of entry into the cell and integration of the HIV-1 genome into the host genome, the virus encounters many host cofactors, primarily interacting with the...