Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: University of British Columbia
Principal Investigator: Sriram Subramaniam
We seek to understand the entry mechanisms of enveloped viruses for three viral families having broad health impact worldwide: coronaviruses such as SARS CoV 2, retroviruses such as HIV 1, and orthomyxoviruses such as influenza A H1N1. The project...
Lead Institution: Yale University
Principal Investigator: Yong Xiong
After attaching to the cell surface and membrane fusion, HIV releases the viral capsid into the target cells, which is transported to the cell nucleus. Evidence suggests that dynein-dynactin-BicD2 complex plays key roles in this retrograde movement...
Lead Institution: University of Utah
Principal Investigator: Christopher Hill
Our goal is to determine the structure of the insulin receptor (IR) ectodomain bound to non-insulin peptide modulators of the receptor. We are studying two peptides that share a high degree of sequence similarity but result in either agonistic or...
Lead Institution: University of California, San Diego
Principal Investigator: Faik Tezcan
Despite advances in protein design, constructing artificial protein nano-architectures with desired structures, functions and dynamics remains a formidable challenge. Our group has developed chemical strategies inspired by principles of inorganic...
Lead Institution: University of British Columbia
Principal Investigator: Natalie Strynadka
Our vision is to develop and use structural biology methods to characterize membrane-associated protein assemblies relevant to antibiotic resistance and bacterial pathogenicity. We are particularly interested in understanding how antibiotic...
Lead Institution: Baylor College of Medicine
Principal Investigator: Ming Zhou
Diacylglycerol O-acyltransferase-1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in mammals. DGAT1 belongs to the superfamily of membrane-bound O-acyltransferases (MBOAT) that are found in all...
Lead Institution: University of Michigan
Principal Investigator: Alys Peisley
Inwardly rectifying K+ (Kir) channels are an important class of K+ channels that conduct K+ ions on hyperpolarization, rather than on depolarization as in other K+ channels. We are using cryo-EM to determine the structure of tetrameric inwardly...
Lead Institution: University of Michigan
Principal Investigator: Uhn-soo Cho
Methane to methanol conversion is critical for environmental health, reducing greenhouse gas, and utilizing the natural gas as an alternative energy source. Methanotrophic bacteria utilize the methane (CH4) as a sole source of carbon and energy by...
Lead Institution: University of Utah
Principal Investigator: Christopher Hill
Our lab reported that the transcriptional regulator, Spt6, contains a tandem-SH2 domain that binds RNA pol II through a novel interaction that requires multiple phosphorylation site on the Rpb1 linker (Sdano, 2017). Subsequently, we have discovered...
Lead Institution: Northwestern University
Principal Investigator: Yuan He
Among all different types of DNA damages, double strand breaks (DSBs) are viewed as the most toxic ones that lead to genome instability. Non-homologous end-joining (NHEJ) pathway, in which the two broken DNA ends are directly ligated without...