Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Oregon Health & Science University
Principal Investigator: Eric Gouaux
NMDA receptors are a member of the ionotropic glutamate receptor family, responsible for transmission of the main component of the fast excitatory neurotransmission in the central nervous system. Anti-NMDA receptor encephalitis is an autoimmune...
Lead Institution: Oregon Health & Science University
Principal Investigator: Liman Zhang
As of February 25th, 2020 there were 80,146 confirmed cases of SARS-Cov-2 infection across the globe. However, no vaccine or drug is available to prevent or treat the infection. Spike protein of SARS-Cov-2 recognizes a host receptor ACE2, is...
Lead Institution: University of North Carolina at Chapel Hill
Principal Investigator: Elizabeth Shank
In bacterial communities, genetically identical bacteria differentiate into functionally and transcriptionally distinct cell types. In the soil environment, certain cell types carry out essential biological functions, including degrading fungal-...
Lead Institution: Oregon Health & Science University
Principal Investigator: Eric Barklis
Despite advances in AIDS diagnosis and treatment, the continuing AIDS epidemic demands continuing efforts to understand all aspects of HIV replication and to develop new methods for its inhibition. One target for viral interference is the...
Lead Institution: Rutgers University
Principal Investigator: Arek Kulczyk
Laminins (Lms) are heterotrimeric glycoproteins required for the assembly of basement membranes (BMs) and are involved in embryonic differentiation, tissue maintenance and wound repair. Defective Lms disrupt BMs to cause diseases of muscle, nerve,...
Lead Institution: New York University School of Medicine
Principal Investigator: David Stokes
Cation Diffusion Facilitators are membrane transporters responsible for homeostasis of transition metals, such as Zn, Mn and Co. We are studying a bacterial homolog called YiiP, which like Znt mammalian homologs, function as Zn/H antiporters....
Lead Institution: University of Pennsylvania
Principal Investigator: Kenji Murakami
Eukaryotic gene expression by RNA polymerase II (pol II) requires the orchestration of a large number of factors during each stage of transcription. Proper gene regulation underlies organismal development, environmental response, and can be...
Lead Institution: Fred Hutchinson Cancer Research Center
Principal Investigator: Betty Shen
Nuclease enzymes are of enormous importance for a wide range of biological and biotechnology disciplines that require site-specific DNA manipulations. Bacterial R-M systems consist of a restriction endonuclease that specifically cleaves an...
Lead Institution: Oregon Health & Science University
Principal Investigator: Show-Ling Shyng
The ATP-sensitive potassium (KATP) channel formed by four Kir6.2 and four SUR1 subunits regulate insulin secretion in ?-cells by coupling glucose metabolism with membrane excitability. Mutations in the ?-cell KATP channel causes abnormal insulin...
Lead Institution: Emory University
Principal Investigator: Eric Ortlund
Nuclear receptors (NRs) sense changes in lipid metabolite levels to trigger specific patterns of gene regulation, which drive critical biological processes including metabolism, development, and inflammation. Liver receptor homolog-1 (LRH-1) is a NR...