Environmental Molecular Sciences Laboratory

A DOE Office of Science User Facility

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User Projects

The following is a list of projects that have been active over the past three years.
For a comprehensive list of projects, see All Projects. You can also search for released data.
Lead Institution: Oregon State University
Principal Investigator: Gaurav Sahay
Lipid-based nanoparticles (LNPs) are a highly efficient way to encapsulate and safely transport nucleic acids past the cellular wall. In the last decade, nucleic acid therapeutics have expanded towards the realm of ribonucleic acids (RNA), enabling...
Lead Institution: University of British Columbia
Principal Investigator: Natalie Strynadka
Our vision is to develop and use structural biology methods to characterize membrane-associated protein assemblies relevant to antibiotic resistance and bacterial pathogenicity. We aim to illuminate the mechanism and specificity of these targets...
Lead Institution: University of Pennsylvania
Principal Investigator: Roberto Dominguez
Our goal is to determine the structural-functional mechanism by which the BAR domain protein PICK1 controls the trafficking of synaptic receptors, including AMPA and the dopamine transporter. Synaptic receptor trafficking affects synaptic strength,...
Lead Institution: University of Michigan
Principal Investigator: Melanie Ohi
Using cryo-EM we determined the structure of the 5.6 MDa H. pylori Cag T4SS at a resolution of ~3.6 Å. The Hp T4SS is structurally different from T4SS structures seen in other species and has an unexpected symmetry mismatch between the 14-fold outer...
Lead Institution: University of British Columbia
Principal Investigator: Calvin Yip
One of the major developments in cancer treatment has been the use of cancer immunotherapy to utilize the immune system to target and destroy cancer cells. The phosphoinositide 3-kinase (PI3K) pathway is at the crossroads of both cancer development...
Lead Institution: University of Wisconsin, Madison
Principal Investigator: Yongna Xing
Protein phosphatase 2A (PP2A) is an essential and major serine/threonine phosphatase in all eukaryotic cells, and regulates multiple cellular processes and signaling events. Deregulation of PP2A and alterations in its subunits are implicated in...
Lead Institution: Emory University
Principal Investigator: Eric Ortlund
Thioesterase superfamily member 1 (Them1) suppresses thermogenesis in brown adipose tissue through hydrolyzing acyl-CoA destined for beta-oxidation. Ablation of Them1 in mice increases energy expenditure and prevents diet-induced obesity and other...
Lead Institution: Emory University
Principal Investigator: Christine Dunham
In every living organism, protein synthesis (translation) is catalyzed by a large, dynamic RNA-protein macromolecular complex called the ribosome. We use biochemical, structural and functional approaches to understand the molecular mechanisms that...
Lead Institution: Oregon Health & Science University
Principal Investigator: Bradley Tebo
This project aims to obtain high-resolution atomic structure of the first purified bacterial manganese-oxidizing complex, Mnx. This complex, containing the novel multicopper oxidase MnxG enzyme, has opened a new chapter in bioinorganic chemistry and...
Lead Institution: Oregon Health & Science University
Principal Investigator: Liman Zhang
The Major Histocompatibility complex (MHC) is critical in immune system for T cell maturation and self vs nonself discrimination, thus expression of MHC genes has to be tightly regulated. Active transcription of MHC is initiated by multiple...