Biosystem Dynamics & Design

Biosystem Dynamics and Design focuses on regulation of spatial and temporal parameters of metabolic processes in microbes, fungi, and plants. By gaining a detailed understanding of how biological systems respond to and modify their environment, EMSL can improve strategies for modifying and manipulating plants, fungi and microbes to advance systems biology for bioenergy and biorenewables.

Within this science theme, EMSL will employ our research and that of our users for:

  • Metabolic compartmentalization: Integrate molecular-scale information to determine the design principles underlying biological compartments, structures and networks such as lipid particles and peroxisomes in plants and fungi, and the carboxysome in cyanobacteria.

Leads

(509) 372-4759

Dr. Baker is the science theme lead for Biosystem Dynamics and Design, which focuses on spatial and temporal dynamics of biological pathways in microbes, fungi and plants to advance our understanding of the carbon cycle and accelerate production...

Instruments

Research Applications Characterization of quadrupolar nuclei for inorganic and biological materials and natural sediments Cryogenic NMR capabilities...
Custodian(s): Nancy Washton
Highlighted Research Applications EMSL's Bruker 500-MHz WB spectrometer is uniquely tailored for in vivo studies: Microbial biofilms relevant to...
Type of Instrument:
Nuclear Magnetic Resonance Spectrometer (NMR)
Research Applications Characterization of quadrupolar nuclei for materials and biological samples Characterization of terrestrial carbon in plant...
Custodian(s): Andrew S Lipton
Highlighted Research Applications Metabolomics Targeted and untargeted metabolomics profiling Structure determination of unknown metabolites...
Custodian(s): David Hoyt
Highlighted Research Applications Metabolomics (Primary focus for this instrument) Targeted and untargeted metabolomics profiling Structure...
Custodian(s): David Hoyt

Publications

Post-translational modifications (PTMs) play an important role in various biological processes through changing protein structure and function. Some...
The oxidation–reduction potentials of electron transfer proteins determine the driving forces for their electron transfer reactions....
Prokaryotes, due to their moderate complexity, are particularly amenable to the comprehensive identification of the protein repertoire expressed...
Background: Extracorporeal membrane oxygenation (ECMO) provides a rescue for children with severe cardiac failure. We previously showed that...
Hydrogen polysulfides (H2Sn, n>1) have been recently suggested to be the actual signalling molecules that involved in sulfur-related redox...

Science Highlights

Posted: March 20, 2017
The Science Molds produce a wide range of both valuable and toxic molecules, which have important implications for energy production, agriculture...
Posted: March 09, 2017
The Science The abundance of woody deciduous shrubs is increasing in the Arctic and this changing vegetative landscape could profoundly impact the...
Posted: February 03, 2017
The Science Photosynthetic bacteria are major primary producers on Earth, using sunlight to convert inorganic compounds in the environment into more...
Posted: February 01, 2017
The Science Vitamin B12 regulates the production of DNA and many proteins required for normal cellular function. A recent study revealed this...
Posted: December 05, 2016
The Science A recent study demonstrated enormous potential for scientists to explore extremely complex molecular mixtures and systems frequently...

Instruments

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our...
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our...
The specific functions of lipids are related to their chemical and physical properties and depend on specific molecular structures. Despite...
Barotrauma as a result of passage through hydroelectric dams is a concern in fish mortality. Here we propose analysis of gas from fish bladders of...
A critical step in the lignocellulosic biofuels pipeline is the extraction of fermentable sugars from plant biomass. Extracellular fungal enzymes are...

Biosystem Dynamics and Design focuses on regulation of spatial and temporal parameters of metabolic processes in microbes, fungi, and plants. By gaining a detailed understanding of how biological systems respond to and modify their environment, EMSL can improve strategies for modifying and manipulating plants, fungi and microbes to advance systems biology for bioenergy and biorenewables.

Within this science theme, EMSL will employ our research and that of our users for:

  • Metabolic compartmentalization: Integrate molecular-scale information to determine the design principles underlying biological compartments, structures and networks such as lipid particles and peroxisomes in plants and fungi, and the carboxysome in cyanobacteria.

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