Alejandro Heredia-Langner

Optimization of peptide identification from tandem mass spectral data

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

William Cannon

Project type

Exploratory Research

Determining the correct sequence of amino acids for a peptide starting with MS/MS spectral data can be stated as an optimization problem where the objective is to match an experimental spectrum with…

Network analysis of soil organic matter molecular chemistry to enable more robust modeling of C cycle along ecosystem gradients

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Nancy Hess

We will explore graphical network analysis of ultra-high resolution FTICR-MS datasets as the first step to derive a quantitative measure of soil organic matter quality that can inform microbially…

NMR profiling of monoclonal antibodies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

High resolution solution state NMR spectroscopy will be used to profile monoclonal antibodies. Two antibodies will be studied, 1) a candidate NIST standard Fab domain, and 2) trastuzumab, an FDA…

Tracking the Fate of new C in Northern Peatlands by a Compound-Specific Stable Isotope-Labeling Approach coupled with FISH-NanoSIMS

Lead Institution

University of Arizona

Principal Investigator

Malak Tfaily

Here, we propose to examine the priming effect, drivers, and dynamics of the "new C" that is stimulated by climate change in Northern peatlands soil using a stable isotope labeling approach…

Bioinformatics Tools to Define the Proteomic State of the Cell

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

William Cannon

Project type

Capability Research

During the next three years we intend to enhance mass spectrometry-based proteomic analysis by building a new generation of tools for peptide identification. The accurate identification of protein…

Projects

Optimization of peptide identification from tandem mass spectral data

Network analysis of soil organic matter molecular chemistry to enable more robust modeling of C cycle along ecosystem gradients

NMR profiling of monoclonal antibodies

Tracking the Fate of new C in Northern Peatlands by a Compound-Specific Stable Isotope-Labeling Approach coupled with FISH-NanoSIMS

Bioinformatics Tools to Define the Proteomic State of the Cell