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Alejandro Heredia-Langner

Institution
Pacific Northwest National Laboratory

Projects

Optimization of peptide identification from tandem mass spectral data

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
William Cannon
Project type
Exploratory Research
Determining the correct sequence of amino acids for a peptide starting with MS/MS spectral data can be stated as an optimization problem where the objective is to match an experimental spectrum with…

NMR profiling of monoclonal antibodies

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Cort
High resolution solution state NMR spectroscopy will be used to profile monoclonal antibodies. Two antibodies will be studied, 1) a candidate NIST standard Fab domain, and 2) trastuzumab, an FDA…

Bioinformatics Tools to Define the Proteomic State of the Cell

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
William Cannon
Project type
Capability Research
During the next three years we intend to enhance mass spectrometry-based proteomic analysis by building a new generation of tools for peptide identification. The accurate identification of protein…