Brian Hoffman

Northwestern University

0000-0002-3100-0746

Projects

Nitrogen Fixation by Nitrogenase

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

Project type

Large-Scale EMSL Research

The bacterial catalyst for N2 fixation is a multi-subunit metalloenzyme comprising two electron carrier Fe proteins and the MoFe protein core. This complex catalyzes the reduction of N2 to NH3 and H2…

Multi-scale investigation of the nitrogen fixation mechanism of Mo-dependent nitrogenase

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

Project type

Large-Scale EMSL Research

We propose to use EMSL NMR and supercomputing resources to gain a molecular level understanding of how substrate binding, electron, and proton delivery is controlled by the nitrogenase metalloenzyme…

Dinitrogen Activation and Electron and Proton Delivery in the Nitrogenase Complex

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

Project type

Large-Scale EMSL Research

We are requesting EMSL supercomputing resources to tackle the mechanism of electron and proton delivery to dinitrogen (N2) to yield ammonia (NH3) in the Mo-dependent nitrogenase -- biological…