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Charles Timchalk

Institution
Pacific Northwest National Laboratory

Projects

Non-Invasive Monitoring for Occupational Exposure to Metals

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Charles Timchalk
Project type
Exploratory Research
The assessment of the potential for health effects, and the need for protective measures requires the accurate measurement of exposure, and the ability to translate these measurements into dose. …

Nanoparticles-Based Biosensors for Detection of Environmental Biomarkers

Lead Institution
Washington State University
Principal Investigator
Yuehe Lin
Project type
Large-Scale EMSL Research
Human exposure to toxic chemical agents (i.e. pesticides, nerve agents) and infectious agents, such as pathogens, may have some immune response, which is composed of both cellular and acellular…

Imaging Respiratory Structure and Function In Laboratory Animals

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live…

MRI of chronic obstructive pulmonary disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques…

In-Vivo 1H NMR Spectroscopy of Pesticide Induced Neurotoxicity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Charles Timchalk
Project type
Limited Scope
The developing brain is uniquely vulnerable to xenobiotic exposures at levels that do not appear to adversely impact adult brain function. In children, learning disabilities, neurological…

Mass Spectrometry Imaging of Microbial Communities

Lead Institution
University of California, San Diego
Principal Investigator
Pieter Dorrestein
Project type
Large-Scale EMSL Research
Despite our significant technological advancements, the solutions to many of humanities lingering problems such as bioremediation of toxic heavy metal environmental contaminants, creation of…