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David Camp

Institution
Pacific Northwest National Laboratory

Projects

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Proteomic Characterization of Alcoholic Hepatitis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
This proposal focuses on the application of sensitive liquid chromatography-mass spectrometry (LC-MS) platforms for the broad detection and quantification of protein abundances towards the molecular…

Alpha Project Phosphoproteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
The project goal is to use mass spectrometry to identify pathway proteins and the sites of their associated post-translational modifications including phosphorylation and ubiquitinylation in response…

Technology development in support of NCRR

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Nancy Colton
The Pacific Northwest National Laboratory (PNNL) has built a facility that already stands at the forefront of proteomic research. Moreover, the Center is uniquely poised for future developments. We…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

WaNPRC Macaque Proteomics for Models of Influenza Infection and AIDS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Brown
Under PNNL Project 49561 the Biological Systems Analysis and Mass Spectrometry (BSAMS) group is the Proteomics Core for the NIH NCRR P51 Washington National Primate Research Center (WaNPRC),…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

WaNPRC Macaque Proteomics for Models of Influenza Infection and AIDS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Abstract for PNNL Project 49651 - Resource Owner Under PNNL Project 49561 the Biological Systems Analysis and Mass Spectrometry (BSAMS) group is the Proteomics Core for the NIH NCRR P51 Washington…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

Longitudinal Proteomic Characterization of Human Cerebrospinal Fluid

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
In order to facilitate future studies of diseased or drug-altered biological conditions by monitoring human cerebrospinal fluid (CSF) it is necessary to begin by creating a database/roadmap or…

Urinary Proteome Monitoring for Transplant Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
We propose to achieve the objective of identifying novel urinary biomarkers for selected categories of renal transplant injury in two phases. We will first employ a discovery phase to comprehensively…

Proteomic Analysis of the HMEC Mitogenic Response

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Brian Thrall
Project type
Exploratory Research
This EMSL User Proposal is for a collaborative effort with the PNNL Proteomic National Center for Research Resources. Recent studies from our and others’ laboratories have demonstrated that the…

Longitudinal Proteomic Characterization of Human Cerebrospinal Fluid

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
In order to facilitate future studies of diseased or drug-altered biological conditions by monitoring human cerebrospinal fluid (CSF) it is necessary to begin by creating a database/roadmap or…

High throughput FTICR Strategies for the Molecular Analysis of Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Exploratory Research
This human proteome project focuses on the development of a global accurate mass and time (AMT) tag database using cultured human mammary epithelial cells (HMEC). The generation of AMT tag databases…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Proteomic analysis of the cyanobacterium Synechocystis sp. PCC 6803

Lead Institution
Washington University in St. Louis
Principal Investigator
Himadri Pakrasi
Project type
Exploratory Research
Cyanobacteria are oxygenic photo-autotrophic prokaryotes that are responsible for roughly 50% of the primary productivity in oceans and lakes. Among the oxygenic photosynthetic organisms…

WRI Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The aim of this pilot project is to obtain comprehensive data on protein expression from breast tumor samples in the WRI tissue repository from patients that are stratified by having negative or…

Characterization of the tumor cell lamellipodia phosphoproteome

Lead Institution
University of California, San Diego
Principal Investigator
Richard Klemke
Project type
Exploratory Research
This new collaborative project under PNNL’s NCRR Biomedical Technology Resource Center is to initiate the characterization of the tumor cell lamellipodia phosphoproteome leading to publication and…

Alpha Project

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Exploratory Research
The Alpha Project employs a multidisciplinary approach that focuses on the prediction of quantitative events in a biological system through the investigation of functional genomics in combination…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Project type
Exploratory Research
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

NCI-III

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Exploratory Research
The first phase of this project focuses on following 5 specific milestones agreed to by the review committee. Scientific milestone 1: Demonstrate the ability to process and analyze soluble stable…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

Role of Human Cytomegalovirus in the Acceleration of Vascular Disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
While the identification and functional characterization of HLA alleles have had widespread success in reducing the incidence of organ rejection immediately following transplantation, infection with…