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Ernesto Nakayasu

Institution
Pacific Northwest National Laboratory

Projects

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

EMERGING VIRUS-HOST CELL PROTEIN INTERACTION NETWORKS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Ernesto Nakayasu
The overall goal of this proposal is to identify and characterize cellular proteins that bind to viral hemorrhagic fever viruses. Specifically, we focus on RNA viruses from four families: the…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

EMERGING VIRUS-HOST CELL PROTEIN INTERACTION NETWORKS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Ernesto Nakayasu
The overall goal of this proposal is to identify and characterize cellular proteins that bind to viral hemorrhagic fever viruses. Specifically, we focus on RNA viruses from four families: the…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

A Molecular Atlas of the Developing Lung

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

Metabolic Landscape of the Aging Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Aging is a major risk factor for the majority of acute and chronic diseases of the lung, including emphysema, pulmonary fibrosis, and lower respiratory tract infections. In this study we will…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

NMR-based metabolomics of the enteropathogens Salmonella and Yersinia

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Large-Scale EMSL Research
The goal of this research is to analyze and reconstruct intercellular and intracellular networks in Salmonella and Yersinia using multiple types of -omics data. Although we hope to gain a more…

Proteomic Assessment of Genes of Unknown Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Understanding the full repertoire of biological functions has proven elusive, hampering our ability to predict outcomes of biological processes, such as infections or impacts of toxins. PNNL will…

Multi-omic 3D tissue maps for a Human BioMolecular Atlas

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Spatially resolved molecular maps of mammalian organs hold significant promise in providing a deeper under-standing of human organ functioning in health and disease states. Fundamental to this is an…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Proteomic Assessment of Genes of Unknown Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Understanding the full repertoire of biological functions has proven elusive, hampering our ability to predict outcomes of biological processes, such as infections or impacts of toxins. PNNL will…