Evan Kantrowitz

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Lead Institution

Boston College

Principal Investigator

Evan Kantrowitz

Project type

Capability Research

Alkaline phosphatase (AP) is a ubiquitous enzyme, which is extremely important in mammals. The enzyme catalyzes the hydrolysis of phosphomonoesters providing the cell with the free alcohol and…

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Lead Institution

Boston College

Principal Investigator

Evan Kantrowitz

Project type

Capability Research

Alkaline phosphatase (AP) is a ubiquitous enzyme, which is extremely important in mammals. The enzyme catalyzes the hydrolysis of phosphomonoesters providing the cell with the free alcohol and…

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Lead Institution

Boston College

Principal Investigator

Evan Kantrowitz

Project type

Capability Research

Alkaline phosphatase (AP) is a ubiquitous enzyme, which is extremely important in mammals. The enzyme catalyzes the hydrolysis of phosphomonoesters providing the cell with the free alcohol and…

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

As early as 1869 it was known that zinc is an essential element for eukaryotes, it is the second most abundant trace element in humans after iron. About half of all proteins contain metal cations,…

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

This project will utilize ab initio molecular orbital theory to aid in the interpretation of the measured field gradients and shielding tensors. These calculations utilize NWCHEM (developed in the…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

The critical nature of zinc in biology requires a detailed understanding of the chemistry, structure, and bondings of these zinc complexes and how, in turn, these manifestations alter the chemistry…

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Lead Institution

Boston College

Principal Investigator

Evan Kantrowitz

Project type

Capability Research

Alkaline phosphatase (AP) is a ubiquitous enzyme, which is extremely important in mammals. The enzyme catalyzes the hydrolysis of phosphomonoesters providing the cell with the free alcohol and…

EMSL Science Overview

Evan Kantrowitz

Projects

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Correlation of Structure and Function of Zinc Metalloproteins Via Solid-state NMR Methods

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Probing the Mechanism of the Alkaline Phosphatase Reaction by 67Zn and 25Mg NMR