Galya Orr

Multiplexed high resolution fluorescence imaging in plants

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

This proposal covers work done under a DOE-funded project led by the University of Missouri. The project focuses on developing and demonstrating the application of a fluorescence microscopy platform,…

Nanoscale Insight into the Living Cell Membrane Responses to Ultrafine PM (Orr LDRD-EBI, PNNL Scope #49989)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Exploratory Research

Ultrafine particulate air pollutants exert harmful effects on human health to a greater extent than other fine particulate matter (PM), and these effects have been linked to the surface properties of…

Molecular mechanisms underlying nanomaterial toxicity or biocompatibility

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Accumulating observations demonstrate the potential of engineered nanoparticles (NPs) to induce adverse effects in vivo and in vitro, but the properties that make a particle toxic or biocompatible…

Advancing Materials for Quantum Information Science: CVD Growth and Functionalization of Graphene with Ordered Arrays of Nanodiamonds

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Marvin Warner

Quantum information science is an up and coming area of research aimed to transform computing capabilities in the future. The use of quantum bits, or qubits, in place of traditional bits is predicted…

SyPro Poplar: Improving Poplar Biomass Production under Abiotic Stress Conditions: an
Integrated Omics, Bioinformatics, Synthetic Biology and Genetic Engineering Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Amir Ahkami

To engineer bioenergy crops that can grow in dry, marginal lands, this project will introduce into poplar trees tolerance to different environmental stresses such as water deficit, high soil salinity…

FRET Screening of Protein-Protein Interactions in Shewanella (Orr GTL-Imaging, PNNL/ORNL Scope #43930)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Exploratory Research

Fluorescence resonance energy transfer (FRET) imaging and spectroscopy techniques will be used to identify specific molecular interactions among proteins in Shewanella. The techniques incorporate…

Membrane Biology Research Campaign: Use of synthetic biology to probe molecular machines in photosynthesis

Lead Institution

Washington University in St. Louis

Principal Investigator

Himadri Pakrasi

Project type

Research Campaign

We have shown in our previous EMSL collaborations our ability to develop systems-level models of cyanobacterial processes. In the present proposal, our objective is to characterize and…

Tracking the Fate of new C in Northern Peatlands by a Compound-Specific Stable Isotope-Labeling Approach coupled with FISH-NanoSIMS

Lead Institution

University of Arizona

Principal Investigator

Malak Tfaily

Here, we propose to examine the priming effect, drivers, and dynamics of the "new C" that is stimulated by climate change in Northern peatlands soil using a stable isotope labeling approach…

Quantitative multiplexed analysis of gene and protein expression patterns in intact cells

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Dehong Hu

Understanding the function of metabolic and regulatory pathways requires identifying their spatial and temporal expression patterns under different conditions. Furthermore, predictive modeling and…

EMSL Science Overview

Galya Orr

Projects

Multiplexed high resolution fluorescence imaging in plants

Nanoscale Insight into the Living Cell Membrane Responses to Ultrafine PM (Orr LDRD-EBI, PNNL Scope #49989)

Molecular mechanisms underlying nanomaterial toxicity or biocompatibility

Advancing Materials for Quantum Information Science: CVD Growth and Functionalization of Graphene with Ordered Arrays of Nanodiamonds

SyPro Poplar: Improving Poplar Biomass Production under Abiotic Stress Conditions: an
Integrated Omics, Bioinformatics, Synthetic Biology and Genetic Engineering Approach

FRET Screening of Protein-Protein Interactions in Shewanella (Orr GTL-Imaging, PNNL/ORNL Scope #43930)

Membrane Biology Research Campaign: Use of synthetic biology to probe molecular machines in photosynthesis

Tracking the Fate of new C in Northern Peatlands by a Compound-Specific Stable Isotope-Labeling Approach coupled with FISH-NanoSIMS

Quantitative multiplexed analysis of gene and protein expression patterns in intact cells