Galya Orr

High throughput generation of small molecule probes for discovery of unique cellular functions using Substrate Activity Screening

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sankarganesh Krishnamoorthy

We propose a method to demystify the massive catalog of proteins-of-unknown-function accumulated by recent advances in genome sequencing by direct assignment of function. We will query enzyme…

Roles for Membrane Receptors in Cellular Responses to External Cues;
The Case of ErbB4 and Morphology Dynamics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Exploratory Research

Understanding the mechanisms that underlie the cellular responses to the environment has been the subject of intensive research. Membrane proteins are found within the interface between the living…

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia…

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia…

Elucidation of the Roles of Diazotrophic EndoPopulus: Endophyte Communities in Promoting Productivity and Resilience of Populus through Systems Biology Approaches (EndoPopulus)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Amir Ahkami

The plant microbiome, including microbial endophytes living within plants and the epiphytes living on the plant surface, has a profound influence on the productivity and resilience of the host plant…

Roles for Membrane Receptors in Cellular Responses to External Cues; The Case of ErbB4 and Morphology Dynamics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Large-Scale EMSL Research

This proposal is a continuation of research pursued under EMSL User Proposal #22092. Understanding the mechanisms that underlie the cellular responses to the environment has been the subject of…

Molecular mechanisms underlying nanomaterial toxicity or biocompatibility

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Accumulating observations demonstrate the potential of engineered nanoparticles (NPs) to induce adverse environmental and health effects, but the properties that make a particle toxic or…

Advancing Materials for Quantum Information Science: CVD Growth and Functionalization of Graphene with Ordered Arrays of Nanodiamonds

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Marvin Warner

Quantum information science is an up and coming area of research aimed to transform computing capabilities in the future. The use of quantum bits, or qubits, in place of traditional bits is predicted…

Alternative RNA splicing events contribute to the onset of islet dysfunction in type 1 diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

Type 1 diabetes (T1D) is a results from the autoimmune destruction of pancreatic β cells, which are the cells responsible for insulin production and secretion in the boby. Despite T1D is primarily…

EMSL Science Overview

Galya Orr

Projects

High throughput generation of small molecule probes for discovery of unique cellular functions using Substrate Activity Screening

Roles for Membrane Receptors in Cellular Responses to External Cues;
The Case of ErbB4 and Morphology Dynamics

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Elucidation of the Roles of Diazotrophic EndoPopulus: Endophyte Communities in Promoting Productivity and Resilience of Populus through Systems Biology Approaches (EndoPopulus)

Roles for Membrane Receptors in Cellular Responses to External Cues; The Case of ErbB4 and Morphology Dynamics

Molecular mechanisms underlying nanomaterial toxicity or biocompatibility

Advancing Materials for Quantum Information Science: CVD Growth and Functionalization of Graphene with Ordered Arrays of Nanodiamonds

Alternative RNA splicing events contribute to the onset of islet dysfunction in type 1 diabetes