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Garry Buchko

Institution
Pacific Northwest National Laboratory

Projects

Grand Challenge in Membrane Biology

Lead Institution
Washington University in St. Louis
Principal Investigator
Himadri Pakrasi
Project type
Grand Challenge
In this grand challenge, we will use a systems approach to understand the network of genes and proteins that govern the structure and function of membranes and their components responsible for…

Screening protein crystals for XRD data collection at synchrotrons

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Limited Scope
To obtain a diffraction quality crystal it is often necessary to grow many crystals, mount, freeze, and then "shoot" them to see how well they diffract. Sometimes it may take 100s of…

Seattle Structural Genomics Center for Infectious Diseases --Year V

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
The Seattle Structural Genomics Center for Infectious Disease (SSGCID) is funded by the National Institute of Allergy and Infectious Diseases (NIAID) to apply genome-scale approaches in solving…

Structural Biology of the Human High Mobility Group A (HMGA) Proteins

Lead Institution
Washington State University
Principal Investigator
Raymond Reeves
Project type
Capability Research
HMGA1 proteins play a critical role in the adaptive immune response to infectious microorganisms and viruses, affecting gene regulation that stimulates resting lymphocytes into active T-cells by…

Seattle Structural Genomics Center for Infectious Diseases

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
The Seattle Structural Genomics Center for Infectious Disease (SSGCID) is a consortium of four institutions (Seattle Biomedical Research Institue (SBRI), deCODE biostructures, University of…

Seattle Structural Genomics Center for Infectious Diseases - Year VI

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
The Seattle Structural Genomics Center for Infectious Disease (SSGCID) is funded by the National Institute of Allergy and Infectious Diseases (NIAID) to apply genome-scale approaches in solving…

SSGCID - Year VII

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Protecting the nation through innovative scientific discovery is the mission of EMSL and the mission of The Seattle Structural Genomics Center for Infectious Disease (SSGCID). The SSGCID is funded by…

Structure-function correlations of proteins in enamel formation

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Wendy Shaw
Project type
Large-Scale EMSL Research
Heterogeneous nucleation is important in the development of biominerals such as bone, teeth and mollusk shells, but often, initial nucleation events are not understood at a mechanistic level. It is…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

SSGCID Year IX

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
As witnessed by the recent outbreak of Ebola in Africa, developing new drugs to combat emerging and re-emerging infectious diseases is of upmost importance. The National Institute of Allergy and…

Understanding proton movement in [FeFe]-hydrogenase

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Laureanti
This proposed work ultimately aims to understand enzymatic design principles using a highly studied and well-known system by creating a series of mutant metalloenzymes to probe the validity and…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…