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Heather Smallwood

Institution
University of Tennessee
ORCID
ORCID logo 0000-0001-5711-5771

Projects

Protein complexes altered by oxidative stress and determined by FTICR-MS

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Large-Scale EMSL Research
To clarify the dynamics of radical mediated modifications, originating from reactive oxygen species (ROS) produced by macrophages, we analyzed modifications to calmodulin (CaM) using immunoblotting…

Immunodominance hierarchies in influenza specific CD8+ T cell responses

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Large-Scale EMSL Research
The phenomenon of immunodominance has been observed in B cell, CD4+ T cell and CD8+ T cell antigen-specific responses in virtually all types of infection and in tumor immunity model. It is still…

Targeted identification of epigenetic determinants of T cell memory

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Large-Scale EMSL Research
The ability to recognize previously encountered pathogens and rapidly eliminate them is critical to the immune system, as well as vaccine efficacy. A minute fraction of the millions of T cells…

MHC presented peptide quantitation: mass spectrometry methods development

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Limited Scope
The phenomenon of immunodominance has been observed in B cell, CD4+ T cell and CD8+ T cell antigen-specific responses in virtually all types of infection and in tumor immunity model. It is still…

Memory potential is determined by priming epitope number

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Limited Scope
Immunization with an engineered H1N1 influenza A virus disrupted for two dominant CD8+ T cell epitopes led to substantially increased subdominant responses following respiratory challenge with the…