Hugh Mitchell

Multi-Omics Evaluation of Tripartite Associations in Red Alder Roots: Integrated Transcriptomics, Proteomics, Metabolomics and Metabolite Imaging of Red Alder Symbiotic Associations in Root Tissue

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kim Hixson

This proposal presents the unique opportunity to conduct the first ever integrated multi-omics and imaging evaluation of the Alnus rubra (red alder tree)/Frankia alni (bacteria)/Alpova diplophloeus …

Single-Bacterium Transcriptomics Using Nanoliter Microfluidic Droplets

Lead Institution

Brigham Young University

Principal Investigator

Ryan Kelly

RNA-seq has been emerging as an advanced approach to the characterization and quantification of transcriptomes using next-generation sequencing technologies. Nevertheless, most studies target to…

Extracellular Research Thrust for EMSL SSA

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kirsten Hofmockel

This project will develop a conceptual framework that defines the biotic and abiotic mechanisms regulating the persistence of mineral associated organic matter (OM). The specific goals are to…

In situ tracking of carbon flow through the soil microbiome

Lead Institution

Institute of Microbiology of the CAS

Principal Investigator

Petr Baldrian

Project type

Large-Scale EMSL Research

Forest soils represent an environment with high carbon (C) stocks and important hotspots of C turnover and microorganisms are the most important actors in this process. The understanding of the C…

A Multi-Omics Data Exploration and Integration Web Application

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lisa Bramer

In the biological and environmental sciences, data are being generated at an unprecedented rate. There are many scientific discoveries pertinent to DOE missions that are waiting to emerge from high…

Tracking carbon flow through syntrophic interspecies interactions in methanogenic microbiomes

Lead Institution

University of British Columbia

Principal Investigator

Ryan Ziels

Project type

Large-Scale EMSL Research

Determining in situ metabolic processes and interactions among diverse assemblages of microorganisms remains a critical challenge in microbial ecology. Consequently, identifying novel genes and…

SyPro Poplar: Improving Poplar Biomass Production under Abiotic Stress Conditions: an
Integrated Omics, Bioinformatics, Synthetic Biology and Genetic Engineering Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Amir Ahkami

To engineer bioenergy crops that can grow in dry, marginal lands, this project will introduce into poplar trees tolerance to different environmental stresses such as water deficit, high soil salinity…

Evaluating viral activity and infection dynamics during wet-up of dry grassland soils

Lead Institution

University of California, Davis

Principal Investigator

Joanne Emerson

Project type

Exploratory Research

After months of dryness, the first heavy rainfall in Mediterranean climates drives a predictable pulse of CO2 emissions and soil microbial activity each year. Responsive microbial populations begin…

Omics Analysis Portal: A Centralized Platform for Analysis, Integration & Visualization Applications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lisa Bramer

There are many scientific discoveries pertinent to DOE-BER that are waiting to emerge from high-throughput biological data, which are now being generated at an unprecedented rate. Analysis of these…

Validation and functional characterization of transcription factors in wheat using cell-free protein
expression and high-throughput sequencing technologies

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Irina El Khoury

This study aims to validate and functionally characterize a family of transcription factors to understand the differences in their deoxyribonucleic acid binding preferences and their potential impact…

Manipulation of Host Signature Expression Following Respiratory Virus Infection

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Pathogen invasion of host cells causes a myriad of functional changes including alterations of chromatin accessibility often limiting defense responses, shunting of cellular resources to centers of…

Projects