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Jennifer Kyle

Institution
Pacific Northwest National Laboratory

Projects

Spatial Metabolomics and Glycomics for Human Kidneys

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christopher Anderton
Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity and mortality in patients in the US. However, we lack a clear understanding of the major…

Iron, Ferroptosis and Ovarian Cancer

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christopher Anderton
The goal of this proposal is to provide mechanistic information on the role of iron in ferroptosis, test how manipulating pathways of iron and lipid metabolism impact ferroptosis, and explore how…

Determining the Metabolome and Lipidome of Amniotic Fluid Across Gestation

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Chaevien Clendinen
The existing literature suggests that the composition of AF is dynamic and changes across gestation. It is rich in proteins, lipids, oligosaccharides, RNAs, and metabolites that potentially influence…

Multi-Scale Multi-Modality High Resolution Mapping of the Adult Human Lung

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christopher Anderton
The Human Biomolecular Atlas Program (HuBMAP) is entering the production phase, with an emphasis on progressive, high sensitivity and specificity assays, prioritizing spatial biomolecular analysis…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

Molecular analysis of exRNA carrier subclasses

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
As a consortium site, PNNL will perform proteomic and lipidomic analysis of exosome RNA (exRNA) carrier subclass samples generated using differential centrifugation, density gradient centrifugation,…

Determining the roles of sphingolipids in phagocytosis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Phagocytosis is a conserved cellular process that is not only critical to ingest and eliminate invading microbial pathogens but also to clear effete cells, and cellular debris. Phagocytosis also…

A Molecular Atlas of the Developing Lung

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Metabolic Landscape of the Aging Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Aging is a major risk factor for the majority of acute and chronic diseases of the lung, including emphysema, pulmonary fibrosis, and lower respiratory tract infections. In this study we will…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Metabolomics of programmed cell death

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Lipidomics is the study of cellular lipids to understand the function and structure of biological systems. The interaction of lipids with other cellular components, including proteins and…

Integrated Pennycress Resilience Project (IPReP)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Pubudu Handakumbura
Pennycress (Thlaspi arvense) is under development as a winter annual oilseed bioenergy crop for the 80 million-acre U.S. Midwest Corn Belt and other temperate regions including the Pacific Northwest…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Lipidomics of circadian rhythm of vascular function in midlife adults

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
The proposed research study is to perform lipidomics analyses on human blood plasma collected from middle aged participants that underwent a 5-day laboratory circadian rhythm study. The laboratory…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Metabolomic and Lipidomic Analysis of Subjects with Galactosemia

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Galactosemia is a rare, genetic, metabolic disease affecting how the body processes galactose. Classical galactosemia, affecting 1 in 30,000 to 60,000 newborns, is a severe form of the disease…

A Systems Biology Approach to Emerging Respiratory Viral Diseases

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This Systems Biology Program will comprehensively analyze and model the molecular and cellular events and pathogen-host interactions that occur during the course of respiratory virus infection. Our…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

A Multi-Omics Data Exploration and Integration Web Application

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
In the biological and environmental sciences, data are being generated at an unprecedented rate. There are many scientific discoveries pertinent to DOE missions that are waiting to emerge from high…

Effects of Silymarin on the Metabolome

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Silymarin (SM)-derived natural products interact with mammalian biomolecules in a specific and productive manner to cause changes in signal transduction and gene expression in a cell to protect the…

Dissection and Deciphering of the Soil Microbiome

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Janet Jansson
This proposal aims to address key gaps in our knowledge about the composition and functional roles of the tens of thousands of microbial species in soil. Although these microorganisms carry out…

Molecular analysis of exRNA carrier subclasses

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
As a consortium site, PNNL will perform proteomic and lipidomic analysis of exosome RNA (exRNA) carrier subclass samples generated using differential centrifugation, density gradient centrifugation,…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…