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Jianjun Wang

Institution
Wayne State University

Projects

Structural Determination of ApoLp-III/HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is focused on determining the NMR structure of an exchangeable apolipoprotein, apolipophorin-III,that is associated with high-density lipoprotein (HDL).This is an important…

Structural Determination of Apolipoprotein/HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is focused on determining the NMR structure of an exchangeable apolipoprotein, apolipophorin-III, that is associated with high-density lipoprotein (HDL). This is an important,…

NMR structural studies of apoAI/preb-HDL particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in clearing the ?bad cholesterol? from the human blood stream. ApoAI is the most abundant protein…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Cholesterol is a lipid that is necessary for our body. Only those cholesterol molecules that are in excess in the peripheral cells and blood vessels are the ?bad cholesterol? and need to be transport…

Structural Determination of Apolipoprotein A-I/preb-HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in the high-density lipoprotein (HDL) pathway, which clears the "bad cholesterol" from human…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Cholesterol is a lipid that is necessary for our body. Only the cholesterol that is in excess in the peripheral cells and blood vessels are the bad cholesterol and need to be transport by the HDL…

NMR Structural Studies of a 180 kDa HDL Particle

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal centers on exploring NMR study of a 180 kDa HDL particle. In particular, we will concentrate on the NMR study of discoidal HDL particle, which is the initial stage of HDL…

Structural Studies of Apolipoprotein A-I/preb-HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Cholesterol is a lipid that is necessary for our body. Only those cholesterol molecules that are in excess in the peripheral cells and blood vessels are the ?bad cholesterol? and need to be transport…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in clearing the "bad cholesterol" from the human blood stream (reverse cholesterol transport…

NMR Studies of an Exchangeable Apolipoprotein in the Lipid-bound State

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on structural studies of Manduca Sexta apolipophorin-III (apoLp-III) using a combination of nuclear magnetic resonance and molecular biology techniques. ApoLp-III…

NMR Studies of Human Apolipoprotein-E N-terminal Domain

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on NMR structural studies of human apolipoprotein-E (apoE). ApoE plays important roles in several human diseases, including atherosclerosis and Alzheimers diseases…

NMR Studies of Human Apolipoprotein-E

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on NMR structural studies of human apolipoprotein-E (apoE). ApoE plays important roles in several human diseases, including atherosclerosis and Alzheimer's…

NMR Studies of Human Apolipoprotein-E

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on NMR structural studies of human apolipoprotein-E (apoE). ApoE plays important roles in several human diseases, including atherosclerosis and Alzheimer's…

NMR Studies of Human Apolipoprotein-AI

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
In this proposal, we plan to focus on determination of the NMR structure of lipid-free human apoA-I(1-186). ApoA-I is a 243-residue protein (28.1 kDa), which is the main protein component of HDL and…

NMR Studies of Human Apolipoprotein-AI

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
In this proposal, we plan to focus on determination of the NMR structure of lipid-free human apoA-I(1-186) and apoAI(1-209). ApoA-I is a 243-residue protein (28.1 kDa), which is the main protein…

NMR Studies of Human Apolipoprotein-E N-terminal Domain

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on NMR structural studies of human apolipoprotein-E (apoE). ApoE plays important roles in several human diseases, including atherosclerosis and Alzheimer’s diseases…

Structural Determination of the Lipid-bound Conformation of ApoLp-III

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on determining the lipid-bound structure of an exchangeable apolipoprotein, insect apolipophorin-III (apoLp-III), using nuclear magnetic resonance (NMR) and…

NMR Studies of Human Apolipoprotein-AI

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
In this proposal, we plan to focus on determining the NMR structure of lipid-free human apoA-I(1-186). ApoA-I is a 243-residue protein (28.1 kDa), which is the main protein component of HDL, a…