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Jon Jacobs

Institution
Environmental Molecular Sciences Laboratory
ORCID
ORCID logo 0000-0003-0557-7338

Projects

NanoPOTS Proteomic Characterization of Alcoholic Hepatitis liver tissue

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Mass spectrometry (MS) has been used extensively for the analysis of protein abundances in diverse sample types; however, limitations on sample handling and sensitivity have prohibited extension to…

Characterization of TB PE/PPE transport proteins

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Pacific Northwest National Laboratory (PNNL) will perform sensitive mass spectrometry (MS) studies towards identification and quantitation of PE/PPE surface protein isolations and global cell culture…

SIV/HIV Reservoir characterization utilizing nanoscale proteomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
HIV cannot be eradicated by antiretroviral therapies (ART) alone. Although lifelong suppression of HIV replication with ART seems possible, side effects, need for strict adherence, resistance, stigma…

Grand Challenge in Membrane Biology

Lead Institution
Washington University in St. Louis
Principal Investigator
Himadri Pakrasi
Project type
Grand Challenge
In this grand challenge, we will use a systems approach to understand the network of genes and proteins that govern the structure and function of membranes and their components responsible for…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Cyanobacteria Membrane Biology Grand Challenge: Systems Analysis of the Dynamics of Membrane Architecture, Composition, and Function- Proteomic, Metabolomic, and Metallomic Characterization

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Project type
Grand Challenge
The strain Cyanothece sp. ATCC 51142, isolated from benthic waters off the coast near Galveston, Texas, is a unicellular strain approximately 4-7 μm in diameter along the major axis. This…

Identification of Tumor viruses using DTS and Proteomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The Chang/Moore laboratory, in collaboration with PNNL, was awarded new funding to pursue the discovery of novel cancer viruses in hematologic malignancies using a combination of genomic and…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Secretome Analysis of Environmental Nanoparticle Induced Biomarkers

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
A national goal for particulate matter (PM) research centers is to develop biological markers of specific mechanistic pathways that can be used to link findings from animal, human and epidemiological…

Discovery and Qualification of TB Surrogate Markers of Treatment

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The research goal is to develop a blood-based, quantitative, biomarker assay panel using a proven, high sensitivity, multiplexed electrochemiluminescence platform that can in combination with…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Identification of Tumor Viruses using DTA and Proteomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The Chang/Moore laboratory, in collaboration with PNNL, was awarded new funding to pursue the discovery of novel cancer viruses in hematologic malignancies using a combination of genomic and…

Next Generation Clinical Proteomics to Target Human Health Challenges

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Changes in protein expression revealed by proteomics technologies will potentially revolutionize the global understanding of human diseases by characterizing both distinct disease states and disease…

NanoPOTS Proteomic Characterization of Alcoholic Hepatitis liver tissue

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Mass spectrometry (MS) has been used extensively for the analysis of protein abundances in diverse sample types; however, limitations on sample handling and sensitivity have prohibited extension to…

Role of Human Cytomegalovirus in the Acceleration of Vascular Disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
While the identification and functional characterization of HLA alleles have had widespread success in reducing the incidence of organ rejection immediately following transplantation, infection with…

Proteomic Characterization of Alcoholic Hepatitis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
This proposal focuses on the application of sensitive liquid chromatography-mass spectrometry (LC-MS) platforms for the broad detection and quantification of protein abundances towards the molecular…

HIV Proteomic Center for Host-Viral Response Characterization

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
A Pilot Proteomics Center has been established at PNNL that will apply powerful new proteomics technologies to broadly investigate changes in protein abundances resulting from the pathologic events…

Proteomic Characterization of Alcoholic Hepatitis

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
This proposal focuses on the application of sensitive liquid chromatography-mass spectrometry (LC-MS) platforms for the broad detection and quantification of protein abundances towards the molecular…

Proteomics Analysis for the Center for Novel Biomarkers of Response

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The organizing theme for the PNNL U54 Center for Novel Biomarkers of Response, is that identification and validation of persistent modified proteins in plasma will provide specific information about…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

OHSU-PNNL Northwest Co-laboratory for Integrated Omics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Proteomic analysis of the cyanobacterium Synechocystis sp. PCC 6803

Lead Institution
Washington University in St. Louis
Principal Investigator
Himadri Pakrasi
Project type
Exploratory Research
Cyanobacteria are oxygenic photo-autotrophic prokaryotes that are responsible for roughly 50% of the primary productivity in oceans and lakes. Among the oxygenic photosynthetic organisms…

Characterization of the tumor cell lamellipodia phosphoproteome

Lead Institution
University of California, San Diego
Principal Investigator
Richard Klemke
Project type
Exploratory Research
This new collaborative project under PNNL’s NCRR Biomedical Technology Resource Center is to initiate the characterization of the tumor cell lamellipodia phosphoproteome leading to publication and…

Proteomics of HCMV

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Susan Varnum
Project type
Exploratory Research
The HCMV project is an NCRR Biomedical Technology Resource Center project. The main aim of this proposal is to develop and exploit new approaches for comprehensive proteome measurements that will…

Dopamine Replacement Therapy and Parkinson's Disease

Lead Institution
Uppsala University
Principal Investigator
Malin Andersson
Project type
Exploratory Research
Dopamine (DA) replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) is currently the most efficient pharmacotherapy for patients with Parkinson's disease (PD), but with disease…

Discovery and Qualification of TB Surrogate Markers of Treatment

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The research goal is to develop a blood-based, quantitative, biomarker assay panel using a proven, high sensitivity, multiplexed electrochemiluminescence platform that can in combination with…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Project type
Exploratory Research
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

WaNPRC Macaque Proteomics for Models of Influenza Infection and AIDS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Brown
Under PNNL Project 49561 the Biological Systems Analysis and Mass Spectrometry (BSAMS) group is the Proteomics Core for the NIH NCRR P51 Washington National Primate Research Center (WaNPRC),…

Identification of Tumor Viruses using DTA and Proteomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
The Chang/Moore laboratory, in collaboration with PNNL, was awarded new funding to pursue the discovery of novel cancer viruses in hematologic malignancies using a combination of genomic and…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

Next Generation Clinical Proteomics to Target Human Health Challenges

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Changes in protein expression revealed by proteomics technologies will potentially revolutionize the global understanding of human diseases by characterizing both distinct disease states and disease…