Joseph Ford

Draws Implementation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Capability Research

Naturally occurring biominerals possess an impressive array of strength, order and nanostructure. These properties are the direct result of protein controlled nucleation and templated mineral growth…

Identify Biomarkers for COPD (Chronic Obstructive Pulmonary Disease) in Humans using Metabonomic Analysis of Serum and Urine by NMR.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joel Pounds

Project type

Capability Research

Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive disease of the airways that is characterized by a gradual loss of lung function. COPD is a major cause of death and illness…

Investigation of Dynamics of Villin Headpiece Subdomain by Solid-State NMR with the Use of Single-Site Labeling.

Lead Institution

University of Alaska at Anchorage

Principal Investigator

Liliya Vugmeyster

Project type

Large-Scale EMSL Research

Villin headpiece protein subdomain (HP36) is extensively used as a model system for protein folding. A mutation of F58 residue was shown to rupture the native fold. Yet a double mutant involving two…

High Temperature, Large Sample Volume, Constant Flow Magic Angle Spinning NMR Probe for 11.7 T Magnetic Field for In-situ Catalytic Reaction Characterization

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joseph Ford

We propose to develop novel NMR methods complementary to other in-situ spectroscopic techniques to improve our understanding of catalytic processes through in-situ investigations of catalyst,…

Probing the Dynamics of a Protein Hydrophobic Core at Low Temperatures

Lead Institution

University of Alaska at Anchorage

Principal Investigator

Liliya Vugmeyster

Project type

Exploratory Research

Hydrophobic cores are found in the interior of globular proteins and are essential for the formation of the folded state. The core represents a complex dynamical medium reflecting the existence of a…

EMSL Science Overview

Joseph Ford

Projects

Draws Implementation

Identify Biomarkers for COPD (Chronic Obstructive Pulmonary Disease) in Humans using Metabonomic Analysis of Serum and Urine by NMR.

Investigation of Dynamics of Villin Headpiece Subdomain by Solid-State NMR with the Use of Single-Site Labeling.

High Temperature, Large Sample Volume, Constant Flow Magic Angle Spinning NMR Probe for 11.7 T Magnetic Field for In-situ Catalytic Reaction Characterization

Probing the Dynamics of a Protein Hydrophobic Core at Low Temperatures