Jules Nde

University of Washington

0000-0002-1571-5637

Projects

iTopS: integrative topological scores with functional molecular modeling

Lead Institution

University of Kansas Medical Center

Principal Investigator

Mihaela Sardiu

Project type

Large-Scale EMSL Research

The objective of this project is to produce a novel computational prototype to synthesize and visualize the structural models of higher-order protein complexes derived from the existing empirical…

Accurately predict the spatial arrangement of protein complexes from subtomogram images through physics-informed machine learning

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Margaret Cheung-Wyker

Deducing three-dimensional (3D) structures of molecular assemblies from cryo-electron tomography (cryoET) data provides an unprecedented level of detail about biological systems in their native…

Virtual Proteomics (ViP): Integrative modeling of protein assemblies in a cell with constraints from proteomic data and reconstructed images from cryo-electron tomography

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Margaret Cheung-Wyker

The objective of the proposed research is to advance the spatial knowledge of higher-order protein assemblies in a cell by integrating improved image reconstruction from cryo-electron tomography and…