Julia Laskin

Preparation of Novel Catalysts using Ion Soft-Landing

Lead Institution

National Dong Hwa University

Principal Investigator

Wen-Ping Peng

Project type

Large-Scale EMSL Research

Soft landing of low energy gas-phase ion beams onto suitable substrates is a powerful preparative technique with many potential applications. Various classes of compounds (e.g. proteins, metal…

Preparation of Novel Catalytic Materials Using Soft- and Reactive Landing of Ions

Lead Institution

National Dong Hwa University

Principal Investigator

Wen-Ping Peng

Project type

Large-Scale EMSL Research

The proposed work is focused on obtaining a molecular-level understanding of the structure-reactivity relationships of catalytically active small metal clusters and organometallic molecules deposited…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Probing the Reactivity of Organic Particles Using Ion Soft-Landing

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Large-Scale EMSL Research

Formation and atmospheric processing of particulate matter is one of the focus areas emphasized by EMSL. Organic coatings on atmospheric aerosols determine the surface chemistry that particles…

Mass Spectrometry Imaging of Microbial Communities

Lead Institution

University of California, San Diego

Principal Investigator

Pieter Dorrestein

Project type

Large-Scale EMSL Research

Despite our significant technological advancements, the solutions to many of humanities lingering problems such as bioremediation of toxic heavy metal environmental contaminants, creation of…

Pan-OMIC characterization of the molecular determinates of uterine receptivity

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Kristin Burnum-Johnson

The overall objective of this research is to identify uterine molecular targets that influence the window of receptivity for embryo implantation. The rational for the proposed research is that a…

Surface Induced Dissociation of Peptides using FTICR Mass Spectrometry

Lead Institution

The Ohio State University

Principal Investigator

Vicki Wysocki

This work will utilize the unique EMSL 6T FT-ICR mass spectrometer specially configured for SID studies to explore the fragmentation behavior of peptides and small proteins. Ion-surface impact is a…

Sulfur Isotope Fractionation Analysis of Individual Atmospheric Particles

Lead Institution

Purdue University

Principal Investigator

Alexander Laskin

Project type

Large-Scale EMSL Research

We propose a set of laboratory studies focused on understanding of chemical forms, oxidation states, and isotopic fractionation of sulfur in atmospherically aged particles collected in a number of…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Development of Novel Approaches for Analysis of Secondary Organic Aerosols
Using High-Resolution Mass Spectrometry.

Lead Institution

Purdue University

Principal Investigator

Alexander Laskin

The objective of the proposed research is to develop new approaches for advanced detailed characterization of the chemical composition of organic aerosols (OA) that will enable a fundamental…

The Effect of Biogenic-Anthropogenic Interactions on the Physical and Chemical Properties of Atmospheric Organic Aerosols

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Special Science

Understanding the effect of biogenic-anthropogenic interactions on the chemical composition and physical properties of organic aerosols (OA) is important for accurate modeling of the effect of OA on…

Pan-OMIC characterization of the molecular determinates of uterine receptivity

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Kristin Burnum-Johnson

The overall objective of this research is to identify uterine molecular targets that influence the window of receptivity for embryo implantation. The rational for the proposed research is that a…

Chemically Functionalized Surfaces through Ion Soft Landing and their Utilization in Heterogeneous Reactions

Lead Institution

Purdue University

Principal Investigator

Robert Cooks

Project type

Large-Scale EMSL Research

Interaction of hyperthermal energy polyatomic ions with surfaces is an active area of research which falls within the purview of material science, mass spectrometry, imaging and spectroscopy, all…

A Molecular Atlas of the Developing Lung

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Corley

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Surface Induced Dissociation of Polyatomic Ions (J Laskin's BES, PNNL Scope #40457)

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

The general objective of our research is to achieve a fundamental understanding of the reaction kinetics and dynamics of activating and dissociating complex molecular ions. These processes are the…

In-Situ Monitoring Electrode Surface Reactions Using High-Resolution Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)

Lead Institution

Ohio University

Principal Investigator

Hao Chen

Project type

Large-Scale EMSL Research

Probing the real-time chemical processes on the electrode surfaces is crucial for obtaining fundamental understanding of redox mechanisms and the nature of active intermediates involved in…

A Molecular Atlas of the Developing Lung

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Investigation of 4Fe-4S cluster complexes with peptides as the terminl ligand

Lead Institution

Washington State University Tri-Cities

Principal Investigator

You-jun Fu

Fe-S proteins exist in all kinds of organisms and play critical roles as electron transfer agents, catalysts, or O2/Fe sensors. Small molecule analogue complexes have been studied extensively.To get…

Environmental Chemistry of Nitrogen-Containing Organic Compounds in Biomass Burning Aerosols

Lead Institution

University of Montana

Principal Investigator

Robert Yokelson

Project type

Large-Scale EMSL Research

The objective of the proposed research is to advance fundamental understanding of environmental chemistry of NOC present in BBA - the major sources of organic aerosols in the atmosphere. The…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

EMSL CAT IN ANALYTICAL MASS SPECTROMETRY

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

The general objective of our research is to achieve a fundamental understanding of the reaction kinetics and dynamics of activating and dissociating complex molecular ions. These processes are the…

Mechanisms of Fragmentation of Post Translationally Modified Peptides

Lead Institution

University of Melbourne

Principal Investigator

Richard O'Hair

It has recently been demonstrated using a collision-induced dissociation (CID) quadrupole ion trap mass spectrometer that under similar conditions to those where enhanced C-terminal aspartic acid…

Surface-Induced Dissociation of Complex Ions on an LTQ/Orbitrap Mass Spectrometer

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Large-Scale EMSL Research

Mass spectrometry is unique among instrumental analysis techniques in terms of its extraordinary sensitivity, molecular specificity and utility for addressing key questions in a broad range of…

Atmospheric Soil Organic Particles

Lead Institution

Purdue University

Principal Investigator

Alexander Laskin

Recent discovery of atmospheric soil organic particles (ASOP), emitted through previously unrecognized atmosphere-land-surface interactions, suggests that ASOP may have a widespread impact over a…

Metal sulfide clusters in the environment

Lead Institution

University of Delaware

Principal Investigator

Murray Johnston

The role of metal clusters in environmental, physical (precipitation, dissolution) and chemical processes (catalysis) is poorly understood. Our research group?s goal is to understand what types of…

Energetics of Dissociation of Peptide Radical Cations

Lead Institution

The University of Hong Kong

Principal Investigator

Ivan Chu

Our intended studies will utilize time- and energy-resolved SID, combined with an RRKM-based modeling approach, to determine the energetics of dissociation of medium-size molecular radical cationic…

Soft-landing of Peptide Ions on Surfaces

Lead Institution

Purdue University

Principal Investigator

Robert Cooks

Interaction of ions with surfaces is an area of active fundamental research in surface science relevant to a broad range of other scientific disciplines such as materials science, mass spectrometry,…

EPICON: Epigenetic Control of Drought Acclimation in Sorghum

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christer Jansson

Genetic manipulation of crops to increase the presence or intensity of desirable traits has been critical to increasing agricultural productivity. These changes have primarily involved modification…

Reactive and Non-Reactive Deposition of Hyperthermal (1-100 eV) Peptide Ions Surfaces (J Laskin's joint BES/LDRD, PNNL Scope #49904)

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Exploratory Research

Interaction of ions with surfaces is an area of active fundamental research in surface science relevant to a broad range of other scientific disciplines such as materials science, mass spectrometry,…

Determination of the Mo...OX bond strengths in oxomolybdenum model complexes.

Lead Institution

Duquesne University

Principal Investigator

Partha Basu

Based on the available data Holm proposed a thermodynamic scale for the propensity of oxygen atom transfer reaction. Under this scheme the feasibility of a substrate to act as an acceptor is judged…

Understanding the Nucleation, Growth, and Immobilization of Metal Clusters Using First Principles Theoretical Calculations and Mass Spectrometry

Lead Institution

Virginia Commonwealth University

Principal Investigator

Jose Reveles Ramirez

Project type

Large-Scale EMSL Research

The properties of clusters vary substantially with the addition or removal of single atoms. This size-dependent behavior enables tuning of the activity and selectivity of cluster-based catalysts with…

Energy and Entropy Effects in Dissociation of Non-Covalent Complexes: Experimental and Theoretical Investigation of the Structures and Interactions of Glycopeptide Antibiotics-Cell Wall

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Exploratory Research

Energy and Entropy Effects in Dissociation of Non-Covalent Complexes: Experimental and Theoretical Investigation of the Structures and Interactions of Glycopeptide Antibiotics-Cell Wall Non…

Molecular Level Characterization of the Formation of Peptide Hydrogels

Lead Institution

Kansas State University

Principal Investigator

Xiuzhi Sun

Project type

Limited Scope

Peptide hydrogels are considered good injectable materials for drug delivery systems and tissue engineering applications because of their high water content and polymer networks. Most peptide…

Rational Design of Solid-Electrolyte Interfaces for Biofuel Production and Energy Storage

Lead Institution

Universitat Rovira i Virgili

Principal Investigator

Josep Poblet

Project type

Large-Scale EMSL Research

Structure-activity relationships determined from molecular-level investigation of mesoscale assemblies of well-defined clusters are critical to the rational development of improved devices for…

Soft-Landing of Complex Ions on Surfaces

Lead Institution

Purdue University

Principal Investigator

Robert Cooks

Project type

Large-Scale EMSL Research

Interaction of ions with surfaces is an area of active fundamental research in surface science relevant to a broad range of other scientific disciplines supported by the DOE Office of Science such as…

Molecular Characterization of Organic Aerosols from the Los Angeles
Ground Site (CalNex 2010) Using High-Resolution Mass Spectrometry

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Limited Scope

The objective of the proposed project is to perform detailed, molecular level characterization of the chemical composition of organic aerosol (OA) samples collected during the CalNex 2010 study (May…

A Molecular Atlas of the Developing Lung

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Energy and Entropy Effects in Dissociation of Non-Covalent Complexes: A Combined Experimental and Theoretical Investigation

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Large-Scale EMSL Research

Non-covalent interactions play a crucial role in chemistry and biology. Fundamental understanding of weak interactions between molecules is important for a number of areas of research supported by…

Surface-Induced Dissociation of Large Molecules in Mass Spectrometry

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Large-Scale EMSL Research

The general objective of our research is to achieve a fundamental understanding of the reaction kinetics and dynamics of activating and dissociating complex molecular ions, develop molecular level…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

XPS characterizationof ion-beam induced surface modification

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Exploratory Research

Our research is focused on the interaction of an ion beam with self-assembled monolayers (SAMs) of organothiols absorbed on a gold surface. In these experiments low-energy ion beam (1-100 eV)…

Molecular Chemistry of Secondary Organic Aerosol Formed in Photochemical Aging of Primary Anthropogenic Emissions

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Large-Scale EMSL Research

We propose to examine molecular level processes taking place in anthropogenic secondary organic aerosols (SOA) using recently developed tools of high resolution mass spectrometry. The proposed…

Pan-OMIC characterization of the molecular determinates of uterine receptivity

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Kristin Burnum-Johnson

The overall objective of this research is to identify uterine molecular targets that influence the window of receptivity for embryo implantation. The rational for the proposed research is that a…

Activation and Dissociation of Large Molecules in Mass Spectrometry

Lead Institution

Purdue University

Principal Investigator

Julia Laskin

Project type

Large-Scale EMSL Research

This proposal is a continuation of research under EMSL User Proposal #6291. Mass spectrometry is unique among instrumental analysis techniques in terms of its extraordinary sensitivity, molecular…

Molecular Level Understanding of Dissociation of Radical Cationic Glycosylated and Phosphorylated Peptides: Energetics, Dynamics and Mechanisms

Lead Institution

The University of Hong Kong

Principal Investigator

Ivan Chu

Project type

Large-Scale EMSL Research

The goal of this proposed project is to achieve a fundamental understanding of the mechanisms, energetics, and kinetics of specific dissociation pathways of the radical cations of post…

Atmospheric Soil Organic Particles

Lead Institution

Purdue University

Principal Investigator

Alexander Laskin

Recent discovery of atmospheric soil organic particles (ASOP), emitted through previously unrecognized atmosphere-land-surface interactions, suggests that ASOP may have a widespread impact over a…

Analysis of Organic Oligomers Forming Secondary Aerosol from Wood Combustion-Derived Phenols

Lead Institution

University of California, Davis

Principal Investigator

Cort Anastasio

Project type

Large-Scale EMSL Research

Aqueous reactions of phenols will be studied in the laboratory using well defined solutions over a range of conditions (e.g., phenol mixture, oxidant and pH) as surrogates for atmospheric drops. The…

Chemistry of Secondary Organic Aerosol (SOA) in the Ambient Atmosphere: Molecular Level Analysis of Size Resolved SOA Samples Using High Resolution Mass Spectrometry.

Lead Institution

University of California, Berkeley

Principal Investigator

Allen Goldstein

Project type

Exploratory Research

The objective of our research is to study the fundamental chemistry in the formation and aging of secondary organic aerosols (SOA) in the atmosphere. A large fraction of SOA has been shown to be…

A Molecular Atlas of the Developing Lung

Lead Institution

National Institutes of Health

Principal Investigator

Charles Ansong

The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Projects