Keqi Tang

An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids

Lead Institution

University of North Carolina Greensboro

Principal Investigator

Qibin Zhang

TITLE: An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids Abstract: The specific functions of lipids are related to their chemical and physical properties and depend on…

Hybrid Microchip/Capillary Electrophoresis Platform for Rapid, Ultrasensitive Bioanalysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

Capillary electrophoresis (CE) is a powerful analytical separation technique that is widely used for proteomics, pharmaceutical, and biotechnology applications1-3. We propose to develop a rapid,…

Fabrication of Si Templates for the Construction of Monolithic Multi-Electrospray Emitters

Lead Institution

Brigham Young University

Principal Investigator

Ryan Kelly

Project type

Exploratory Research

Electrospray ionization (ESI) has made possible the online coupling of chemical separation techniques such as liquid chromatography with mass spectrometry (MS) for the analysis of large biomolecules …

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Ion Funnel Development (PNNL Scope #48165, K.Tang JPL-Ion Funnel Project)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

Project type

Exploratory Research

Design and construct an electrodynamic ion funnel and associated components suitable for interfacing with the JPL mass spectrometer and laser ablation systems. Characterize and optimize the ion…

An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of lipids are related to their chemical and physical properties and depend on specific molecular structures. Despite technological advancements that have made mass spectrometry…

MICROFABRICATION OF ELECTROSPRAY EMITTER ARRAYS FOR IMPROVED SENSITIVITY IN ELECTROSPRAY IONIZATION-MASS SPECTROMETRY

Lead Institution

Brigham Young University

Principal Investigator

Ryan Kelly

Project type

Exploratory Research

Proposal attached

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

Microfabrication of Electrospray Emitter Arrays for Improved Sensitivity in Electrospray Ionization-Mass Spectrometry

Lead Institution

Brigham Young University

Principal Investigator

Ryan Kelly

Project type

Large-Scale EMSL Research

Liquid chromatography (LC), combined with mass spectrometry (MS), is an extremely powerful platform for protein analysis, allowing complex mixtures first separated by LC to be further resolved and…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Technology development in support of NCRR

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Nancy Colton

The Pacific Northwest National Laboratory (PNNL) has built a facility that already stands at the forefront of proteomic research. Moreover, the Center is uniquely poised for future developments. We…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Theoretical Evaluation of Ion Funnel Focussing for Light Ions in a Drift Tube

Lead Institution

Washington State University

Principal Investigator

Bertram Jobson

Project type

Capability Research

The object of the project is to perform some ion trajectory simulations to evaluate the potential benefit of using an ion funnel to focus light ions in the Proton Transfer Reaction Mass Spectrometer …

Developing a strategy to identify & validate pharmacodynamic kinase inhibitorbiomarkers

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The primary goal of the project is to develop mass spectrometry (MS) based assays capable of globally quantifying changes in kinase-specific phosphorylation stoichiometry. The specific work related…

Evaluate and apply the LC/FAIMS/IMS/TOF MS platform to high throughput quantitative analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

One of the goals of the Clinical Proteomic Technologies for Cancer (CPTC) initiative is to evaluate the performance of proteomic technology platforms and standardizing applications of these platforms…

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

Development of an Ultra-High Throughput and Highly Sensitive Proteomics Instrumental Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Project type

Scientific Partner

This project will develop and initially demonstrate a powerful new "next generation" instrumental platform for ultra-high throughput proteomics that will enable a range of new measurement…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

Validation and Advanced Development of Emerging Technologies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

Develop mass spectrometry (MS) based assays for quantitative biomarker validation with sensitivity and specifically comparable to or better than antibody based immunoassays. The new liquid…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Single Cell Analysis Using Microfluidics Coupled to Ultrasensitive Mass Spectrometry

Lead Institution

Brigham Young University

Principal Investigator

Ryan Kelly

Proteomics and metabolomics measurements in their present form require large populations of cells and thus average over and obscure important heterogeneity that is present even in clonal populations…

An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids

Lead Institution

University of North Carolina Greensboro

Principal Investigator

Qibin Zhang

The specific functions of lipids are related to their chemical and physical properties and depend on specific molecular structures. Despite technological advancements that have made mass spectrometry…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Projects