Kevin Minard | Environmental Molecular Sciences Laboratory

MR Imaging of Respiratory Stucture and Function

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Capability Research

MR imaging methods are being developed to visualize pulmonary mechanics, define airway architecture, and measure the flow velocity of inhaled gases in live rats. Results provide a basis for…

Characterization of In-Vivo 1H-NMR Biomarkers for Pulmonary Phospholipidosis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Capability Research

The primary goal of this project is to test the potential utility of slow MAS 1H-NMR methods for directly monitoring pulmonary phospholipid accumulation in live animals and in real-time. It is…

High Resolution 1H NMR Metabolomics Using Slow and Ultra Slow Magic Angle Spinning

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

Recently, we developed new so-called slow-MAS (magic angle spinning) NMR techniques that significantly enhance the spectral information in biofluids, intact excised tissues, organs and live small…

Aquaporins

Lead Institution

Massachusetts General Hospital East and Harvard University School of Medicine

Principal Investigator

Dennis Brown

Project type

Capability Research

The objective of this multidisciplinary project is to investigate the application of NMR spectroscopy using the newly developed combined confocal/NMR microscope to aquaporin biology. The project is…

Use of NMR Microscopy to examine biofilm structure in porous media under conditions of fluid flow

Lead Institution

Oregon State University

Principal Investigator

Brian Wood

Project type

Capability Research

We propose to continue our investigation of the use of NMR microscopy for resolving the sub-pore-scale structure of biofilms porous media. In the new proposed, work, we will continue to improve the…

Real-Time Imaging of Lignocellulosic Biomass Degradation by Fluorescence Microscopy and Atomic Force Microscopy

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Dehong Hu

Project type

Large-Scale EMSL Research

The degradation of lignocellulosic biomass by enzymes is a potentially important new source for our nation's energy need. However the structure of lignocellulose in plant cell walls and the…

Magnetic Resonance Microscopy of Ozone-Induced Lung Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge.

Imaging Respiratory Structure and Function In Laboratory Animals

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live…

MRI of chronic obstructive pulmonary disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques…

Imaging Of Water and Gas Distribution in PEM Fuel Cell Stacks and Cells

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

The overall objective of this project is to develop three-dimensional magnetic resonance imaging (MRI) for in-situ, real-time monitoring of polymer electrolyte membrane (PEM) fuel cell…

Magnetic Resonance Microscopy of Environmental Lung Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Capability Research

The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge. To accomplish…

In-Vivo 1H NMR Spectroscopy of Pesticide Induced Neurotoxicity

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Charles Timchalk

Project type

Limited Scope

The developing brain is uniquely vulnerable to xenobiotic exposures at levels that do not appear to adversely impact adult brain function. In children, learning disabilities, neurological…

Magnetic Resonance Microscopy of Environmental Lung Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Capability Research

The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge. To accomplish…

Rhizosphere Research Campaign: The plant-soil interface - understanding dynamic interactions in the context of environmental change

Lead Institution

University of Missouri - Columbia

Principal Investigator

Gary Stacey

Project type

Research Campaign

The ultimate, long-term goal is to determine what drives source-sink relationships that control the cycling of plant nutrients belowground. To fully appreciate the complexities of this dynamic…

Development of a Novel Approach for Imaging Inhaled Particulates

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Capability Research

The human respiratory tract is a target for a broad range of airborne particulates that can contribute to a vast array of different diseases. Nevertheless, currently available techniques for…

Development of a Novel Approach for Imaging Inhaled Particulates

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Capability Research

The specific aim of this project is to develop novel Magnetic Resonance (MR) imaging methods for quantifying the location and amount of inhaled particles deposited in the respiratory tract of a live…

High-Resolution Imaging of the Passive Heart and Cardiac Valves for the Next Generation Cardiac Models

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Daniel Einstein

Project type

Capability Research

Parallel to PNNL?s successful efforts to fund a virtual lung project, we seek preliminary data in pursuit of a large-scale computational effort directed at the heart. Software tools for image…

MRI for Understanding Water Management in PEM Fuel Cells

Lead Institution

Brown University

Principal Investigator

Li-Qiong Wang

Project type

Capability Research

Real-time, 3-dimensional analysis methods are currently needed to probe polymer electrolyte membrane (PEM) fuel cell performance and degradation. Magnetic Resonance Imaging (MRI) has tremendous…

Projects