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Kevin Minard

Institution
Pacific Northwest National Laboratory

Projects

Characterization of In-Vivo 1H-NMR Biomarkers for Pulmonary Phospholipidosis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jian-zhi Hu
Project type
Capability Research
The primary goal of this project is to test the potential utility of slow MAS 1H-NMR methods for directly monitoring pulmonary phospholipid accumulation in live animals and in real-time. It is…

Aquaporins

Lead Institution
Massachusetts General Hospital East and Harvard University School of Medicine
Principal Investigator
Dennis Brown
Project type
Capability Research
The objective of this multidisciplinary project is to investigate the application of NMR spectroscopy using the newly developed combined confocal/NMR microscope to aquaporin biology. The project is…

Magnetic Resonance Microscopy of Ozone-Induced Lung Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge.

Imaging Respiratory Structure and Function In Laboratory Animals

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live…

MRI of chronic obstructive pulmonary disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques…

Imaging Of Water and Gas Distribution in PEM Fuel Cell Stacks and Cells

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The overall objective of this project is to develop three-dimensional magnetic resonance imaging (MRI) for in-situ, real-time monitoring of polymer electrolyte membrane (PEM) fuel cell…

Magnetic Resonance Microscopy of Environmental Lung Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge. To accomplish…

In-Vivo 1H NMR Spectroscopy of Pesticide Induced Neurotoxicity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Charles Timchalk
Project type
Limited Scope
The developing brain is uniquely vulnerable to xenobiotic exposures at levels that do not appear to adversely impact adult brain function. In children, learning disabilities, neurological…

Magnetic Resonance Microscopy of Environmental Lung Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge. To accomplish…

Development of a Novel Approach for Imaging Inhaled Particulates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
The human respiratory tract is a target for a broad range of airborne particulates that can contribute to a vast array of different diseases. Nevertheless, currently available techniques for…

Development of a Novel Approach for Imaging Inhaled Particulates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
The specific aim of this project is to develop novel Magnetic Resonance (MR) imaging methods for quantifying the location and amount of inhaled particles deposited in the respiratory tract of a live…

MRI for Understanding Water Management in PEM Fuel Cells

Lead Institution
Brown University
Principal Investigator
Li-Qiong Wang
Project type
Capability Research
Real-time, 3-dimensional analysis methods are currently needed to probe polymer electrolyte membrane (PEM) fuel cell performance and degradation. Magnetic Resonance Imaging (MRI) has tremendous…

MR Imaging of Respiratory Stucture and Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
MR imaging methods are being developed to visualize pulmonary mechanics, define airway architecture, and measure the flow velocity of inhaled gases in live rats. Results provide a basis for…