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Lisa Bramer

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-8384-1926

Projects

Enabling interpretation of MAP results using biological network analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Sara JC Gosline
The Multiomics Analysis Portal (MAP) is a one-stop omics data analysis web portal for EMSL users to perform quality control (QC), visually explore, statistically analyze, and integrate data after the…

Lipidomics of circadian rhythm of vascular function in midlife adults

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
The proposed research study is to perform lipidomics analyses on human blood plasma collected from middle aged participants that underwent a 5-day laboratory circadian rhythm study. The laboratory…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

Semi-Automated NMR Metabolite Identification via Machine Learning

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Javier Flores
Current EMSL metabolomics capabilities enable automated Nuclear Magnetic Resonance (NMR) data acquisition, yet downstream processing of these data is manually intensive and time-consuming. The…

Interpretable Machine Learning for Multivariate Omics Data Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
Often, the ultimate motivation for the generation of omics data for an experiment is a better understanding of an observed phenotype of a biological system and the effect of perturbations on the…

Pore- to Core-Scale Research to Inform Ecosystem-Scale Soil C Biogeochemistry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vanessa Bailey
Project type
Large-Scale EMSL Research
The spatial separation of soil organic carbon (SOC), microbes, and extracellular activity is an important mechanism of SOC protection in soils that exists at the soil pore (micron-mm) scale. The…

Decomposers in Transition

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kirsten Hofmockel
The overarching objective of the research is to develop a scalable approach for understanding how soil decomposer community dynamics are affected by spatial heterogeneity and climate change (drought)…

A Multi-Omics Data Exploration and Integration Web Application

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
In the biological and environmental sciences, data are being generated at an unprecedented rate. There are many scientific discoveries pertinent to DOE missions that are waiting to emerge from high…

Omics Data Integration via Interpretable Machine Learning Models

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
Often, the ultimate motivation for the generation of omics data for an experiment is a better understanding of the biological system; the generation of multiple 'omics datasets for the same…

Semi-Automated NMR Metabolite Profiling Software

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Javier Flores
NMR is powerful tool to identify and quantify metabolites in biological systems, and EMSL's NMR instrumentation makes automated data acquisition routine. However, the key downstream data…

Deep UV laser ablation system for spatial single-cell proteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
William Chrisler
Laser capture microdissection (LCM) is the key capability for spatially resolved omicss. However, commercially available LCM systems are designed for mammalian tissues and feature UV lasers (330 nm),…