Marat Valiev

Enhancing biopreparedness through a model system to understand the molecular mechanisms that lead to pathogenesis and disease transmission

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Margaret Cheung-Wyker

The science of biopreparedness to counter biological threats hinges on understanding the fundamental principles and molecular mechanisms that lead to pathogenesis and disease transmission. Our vision…

Developing a Parallel Blochl Code

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

Project type

Exploratory Research

This project will develop a massively parallel version of Bloch's PAW method. PAW is an all-electron method that combines the adaptability of linear augmented plane wave methods with the…

Fine-Tuning Ambipolar Charge-Transport Properties of Organic Materials By Computational Design

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Asanga Padmaperuma

Project type

Exploratory Research

We propose to use EMSL computational facilities for developing predictive models which will guide the design of new ambipolar organic charge transporting materials. Designing new materials for flat…

The Mechanism of the Hammerhead Ribozyme RNA Cleavage Reaction: Determining Optimized Free Energy Reaction Paths from QM/MM Simulations

Lead Institution

University of California, San Diego

Principal Investigator

John Weare

Project type

Exploratory Research

Ribonucleic acids (RNA) play a central role in the transmission of genetic information. However, the identification of additional non-coding roles of RNA polymers continues to grow. An important…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Design Criteria for Organic Charge Transporting Materials through Computational Modeling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Linda Sapochak

Project type

Large-Scale EMSL Research

ABSTRACT We propose to use EMSL computational facilities for developing predictive models which will guide the design of new organic charge transporting materials for thin film energy conversion…

Theoretical Modeling of Fluorescence Properties in Biological Systems

Lead Institution

Temple University

Principal Investigator

Spiridoula Matsika

Project type

Capability Research

In this project high level ab initio methods will be used to study photophysical properties of nucleic acid bases and their fluorescent analogs. The natural nucleobases have ultrashort excited state…

Cluster Model Studies of Condensed Phase Phenomena

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

This is a request for continuing a previous program (proposal ID 44676) which was closed on September 30, 2012. This program is focused on obtaining a microscopic understanding of solution chemistry…

Agile BioFoundry

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Free radical Reactions in the Catalytic Cycle of Cytochrome bc Complexes

Lead Institution

University of Alabama

Principal Investigator

Michael Bowman

Project type

Large-Scale EMSL Research

The cytochrome bc complex is a large ~750 kiloDalton molecular weight protein complex that is embedded in the mitochondrial or cellular membrane and is a central component of the electron transport…

Ultra-high accuracy simulations for large molecular systems: Exploring the Cutting Edge Limits of NWChem

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karol Kowalski

The main goal of the proposed proposal is to test and apply a new generation of highly scalable electronic structure methods to cutting edge problems that can be viewed as an excellent target for…

Reactivity and dynamics of complex systems

Lead Institution

University of Minnesota

Principal Investigator

Donald Truhlar

Project type

Large-Scale EMSL Research

The project involves an ongoing collaboration of 20+ researchers from University of Minnesota, University of South Carolina, Massachusetts Institute of Technology, and Pacific Northwest National…

Model-Driven Datasets for Plant-Soil-Microbe Interactions using a RhizoCell Experimental System

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Timothy Scheibe

A critical aspect of SSA system-level studies is the iterative integration of models and experiments (ModEx) across multiple physical scales and processes. This project will produce holistic…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Large-Scale EMSL Research

One of the most significant challenges in the metallobiochemistry of Zn2+ is the a priori determination of how the metal center will facilitate a particular chemical reaction. Two examples…

Computational Chemical Dynamics of Complex Systems

Lead Institution

University of Minnesota

Principal Investigator

Donald Truhlar

Project type

Capability Research

The objective of this project is to develop and apply innovative high-performance computing techniques and simulation methods in order to address computationally challenging problems in chemical…

Cluster Model Studies of Condensed Phase Phenomena

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

This is a request for continuing a previous program (proposal ID 47711) which was closed on September 30, 2013. This program is focused on obtaining a microscopic understanding of solution chemistry…

Gas Phase Study of Solution Phase Species and Chemistry Using Variable Temperature Photoelectron Spectrometer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

We propose to investigate solution phase species and chemistry in the gas phase using a recently developed low-temperature photoelectron spectrometer. The subjects include but not limited to,…

Basis of Microbial Membrane Attachment to Mineral Surfaces
and Ionic Contaminants Uptake

Lead Institution

The Ohio State University

Principal Investigator

Brian Lower

Project type

Large-Scale EMSL Research

Allocation of resources at EMSL facilities, both experimental and computational, is sought for the extension of our current DOE-funded biogeochemistry project. The project focus lies on the molecular…

Theoretical Modeling of Fluorescence Properties in Biological Systems

Lead Institution

Temple University

Principal Investigator

Spiridoula Matsika

Project type

Capability Research

In this project high level ab initio methods will be used to study photophysical properties of nucleic acid bases and their fluorescent analogs. The natural nucleobases have ultrashort excited state…

Integrated Experimental and Computational Approach to Molecular Based Characterization of Aerosol Particle Formation

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

The main focus of our project is to provide a comprehensive molecular level characterization of common multicomponent aerosol particles and gain fundamental understating of molecular specific effects…

Development of KBase-NWChem Interface for integration of molecular properties with Genome-Scale Metabolic Modeling

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

One of the challenges to investigate natural and engineered biological systems at molecular-level is to accurately predict chemical properties of thousands of metabolites involved in cell metabolism…

Capture and Reduction of Metal Ions out of the
Environment by Biomolecular Systems

Lead Institution

Universidade Federal de Pernambuco

Principal Investigator

Roberto Lins Neto

Project type

Grand Challenge

The use of microbes and/or microbial components has been proven to be an efficient strategy for in situ environmental remediation technologies. The requested allocation of computer time is for…

(gc3551)Complex Enzymatic Reactions Studied by Molecular Modeling and Electronic Structure Calculations.

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

T. Straatsma

Project type

Capability Research

This proposal concerns the continued development and application of modeling capabilities for the study of complex enzymatic reactions, in particular those that involve electron transfer and/or…

Cluster Model Studies of Condensed Phase Phenomena

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

This program is focused on obtaining a microscopic understanding of solution chemistry and solvation of negatively charged ions using cluster models in the gas phase via combined low temperature…

Development of advanced computational methods for molecular level characterization of complex biological, earth, and environmental systems using NWChem

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

Our project is focused on development of advanced computational capabilities to support molecular level simulations of biological, biogeochemical, and physical processes. These capabilities are…

Computational Chemical Dynamics of Complex Systems

Lead Institution

University of Minnesota

Principal Investigator

Donald Truhlar

Project type

Capability Research

The goal of this project is to apply powerful new simulation techniques to tackle computationally challenging problems in chemical dynamics, with special emphasis on electrochemistry, heterogeneous…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Large-Scale EMSL Research

One of the most significant challenges in the metallobiochemistry of Zn2+ is the a priori determination of how the metal center will facilitate a particular chemical reaction. Two examples…

Study of Depolymerization and Valorization of Lignin

Lead Institution

Joint BioEnergy Institute

Principal Investigator

Seema Singh

Project type

Large-Scale EMSL Research

The primary goal of the proposed work is to study and understand using both experimental and computational approaches, the depolymerization of lignin generated during the ionic liquid (IL)…

Development of Computational Chemistry Tools for Aerosol Chemistry and Molecular-Level Characterization of Secondary Organic Aerosol particles

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Edoardo Apra

Our project is focused on the development of advanced quantum chemistry capabilities to enable molecular level characterization of secondary organic aerosol (SOA) particles and aerosol chemistry. The…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Capability Research

The critical nature of zinc in biology requires a detailed understanding of the chemistry, structure, and bondings of these zinc complexes and how, in turn, these manifestations alter the chemistry…

(gc3563)Molecular Computational Studies In Environmental Chemistry, Geochemistry, and Biogeochemistry

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eric Bylaska

Project type

Capability Research

Addressing the overwhelming environmental cleanup problems facing the Department of Energy?s nuclear production sites as well as other polluted sites in the nation is hampered by a lack of knowledge…

Cluster Model Studies of Condensed Phase Chemical Physics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

This program is focused on obtaining a microscopic understanding of solution chemistry and solvation of negatively charged ions using cluster models in the gas phase via combined low temperature…

Gas Phase Study of Solution Phase Species and Chemistry Using Variable Temperature Photoelectron Spectrometer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

We propose to investigate solution phase species and chemistry in the gas phase using a recently developed low-temperature photoelectron spectrometer. The subjects include but not limited to,…

Molecular Computational Studies In Geochemistry and Environmental Chemistry

Lead Institution

Corning, Inc.

Principal Investigator

James Rustad

Project type

Capability Research

This project is focused on prediction of reaction rates, mechanisms, and associated isotopic fractionation factors of key processes in low-temperature geochemistry. Such processes can play a key role…

(gc3564)Nanostructure Formation, Aggregation, and Reactivity

Lead Institution

Argonne National Laboratory

Principal Investigator

Larry Curtiss

Project type

Capability Research

This project is the outgrowth of several projects currently funded by DOE-BES at PNNL and ANL or new proposals co-authored by the participants and submitted to DOE?s Computational Nanoscience…

Hybrid Quantum Mechanics Molecular Mechanics Simulations of Biological Systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

Biological processes are comprised of complex interconnected chains of chemical reactions. These reactions occur in the presence of extended macromolecular structures that regulate local electronic…

Gas Phase Study of Solution Phase Species and Chemistry Using Variable Temperature Photoelectron Spectrometer and Quantum Chemical Calculations

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

We propose to investigate solution phase species and chemistry in the gas phase using the home-made cryogenic and temperature-dependent photoelectron spectrometer in combination with ab initio…

First Principles Multiscale Analysis of Biochemical Processes: Signal Transduction and Spectroscopic Analysis of Local Structure-Folding Relations in Membrane Proteins

Lead Institution

University of California, San Diego

Principal Investigator

John Weare

Project type

Capability Research

We propose computational work in two application areas: first principles simulation of posttranslation modification in signal transduction in eukaryote cells and the use of spectroscopic methods to…

Cluster Model Studies of Condensed Phase Phenomena Using Temperature-Controlled Photoelectron Spectroscopy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

Project type

Exploratory Research

This program is aimed at obtaining a microscopic understanding of solution chemistry and solvation of negatively charged ions using cluster models in the gas phase. Our primary experimental technique…

Biology in Space and Time (BioSaT) Research Campaign

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

Significant research effort is currently aimed at developing cost effective plant biomass deconstruction for biofuel production. Moreover, the recalcitrance of plant cell walls to rapid degradation…

Development classical density functional methods for coarse grained simulations of biochemical processes

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Marat Valiev

The proposed research is focused on development classical density functional methods for coarse grained simulations of biochemical processes. The computational time is requested on Cascade/Tahoma…

Simulation of Aqueous Mineral Interfaces, and Development of Ab Initio Plane-Wave Methods

Lead Institution

University of California, San Diego

Principal Investigator

John Weare

Project type

Exploratory Research

We will use ab initio plane-wave methods to perform simulations on surface complexes, rearrangements, and micro-solvations of metal-oxide surfaces. These simulations will allow us to study changes…

Cluster Model Studies of Condensed Phase Phenomena at Well-Defined Conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

Project type

Large-Scale EMSL Research

This program is aimed at obtaining a microscopic understanding of solution chemistry and condensed phase phenomena using gas phase clusters as model systems.Our current focus is on the microsolvation…

Identifying the mechanism of bacterial extracellular electron transfer via conductive pili proteins

Lead Institution

Yale University

Principal Investigator

Nikhil Malvankar

Project type

Exploratory Research

Microbial metabolism plays an important role in the global cycling of carbon, nutrients, and metals. Recent discovery of microorganisms sharing energy using direct electrical connections might…

Accurately predict the spatial arrangement of protein complexes from subtomogram images through physics-informed machine learning

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Margaret Cheung-Wyker

Deducing three-dimensional (3D) structures of molecular assemblies from cryo-electron tomography (cryoET) data provides an unprecedented level of detail about biological systems in their native…

Low Temperature (10K) 25Mg Solid-State NMR of DNA Repair Proteins and Their
Complexes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Paul Ellis

Project type

Large-Scale EMSL Research

The chemistry central to the function of the DNA repair proteins apurinic/apyrimidic endonuclease 1 (APE1) and polymerase &#946; (Pol &#946;) is the chemistry of water activated by Mg2+…

Computational and FTIR Spectroscopic Studies of Vibrational and Electronic Properties of Transition Metal Mixed-Valence Complexes in Solution

Lead Institution

University of Washington

Principal Investigator

Munira Khalil

Project type

Exploratory Research

Developing a detailed molecular picture of ultrafast photoinduced electron transfer processes in solution will aid the development of new light harvesting technologies. The goal of this project is to…

Biology in Space and Time (BioSaT) Research Campaign

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

Significant research effort is currently aimed at developing cost effective plant biomass deconstruction for biofuel production. Moreover, the recalcitrance of plant cell walls to rapid degradation…

Ab-initio simulations of the catalytic mechanism in protein kinases

Lead Institution

University of California, San Diego

Principal Investigator

John Weare

Project type

Capability Research

Protein kinase enzymes play an important role in controlling cellular signaling events by catalyzing a phosphorylation reaction in which the gamma-phosphate from an adsorbed ATP in the catalytic…

Studies on 1,2,3-trichloropropane (TCP) and its derivatives

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eric Bylaska

Project type

Large-Scale EMSL Research

The widespread use of 1,2,3-trichloropropane (1,2,3-TCP) as solvents in paint and varnish removal, cleaning and degreasing, etc. has resulted in it becoming an emerging pollutant in the environment …

Projects