Marilyn Jorns

MCP Hahnemann University

Projects

Inactivation of Monomeric Sarcosine Oxidase by a Suicide Substrate

Lead Institution

MCP Hahnemann University

Principal Investigator

Marilyn Jorns

Project type

Exploratory Research

We have recently determined the kinetic mechanism of inactivation of monomeric sarcosine oxidase by N-(cyclopropyl)glycine (CPG), a sarcosine analog which acts as a suicide substrate and covalently…

Use of Mass Spectral Disassembly to Elucidate the Quaternary Structure of the Complex Heterotetrameric Sarcosine Oxidase

Lead Institution

MCP Hahnemann University

Principal Investigator

Marilyn Jorns

Project type

Exploratory Research

The measurement of intact macromolecular assemblies and their disassembly in the mass spectrometer has recently emerged as a powerful new tool in determining protein quaternary structure. …