Michael Taylor

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Tissue-scale or cell-population-level analysis (i.e., ‘bulk analysis’) yields averaged abundance data that can mask critical information about the state of individual cells. Through a recently ended…

Beam ionization: who gets the charge and why do some get broken up about it?

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Beam ionization is the key method for directly probing samples for in situ chemical analysis. We aim to understand the mechanisms of small molecule desorption and ionization from different substrates…

Iron, Ferroptosis and Ovarian Cancer

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The goal of this proposal is to provide mechanistic information on the role of iron in ferroptosis, test how manipulating pathways of iron and lipid metabolism impact ferroptosis, and explore how…

An EMSL User-ready spatially resolved metabolomics platform capable of high-lateral MS imaging and epifluorescence-based targeting

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

To upgrade our laser-ablation electrospray ionization mass spectrometry (LAESI-MS) platform to a capability that can automatically identify cells and areas of interest and acquire spatially resolved…

Soil-like habitats for spatial analysis of microbe-mineral interactions

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Arunima Bhattacharjee

The objective of this study is to develop mineral microfluidics compatible with a suite of optical and chemical imaging capabilities at EMSL, as well as SSRL, for probing microbially relevant…

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The ability to capture and visualize the complex metabolic behavior of living organisms in situ is a bioanalytical grand challenge that has yet to be fully realized. Ambient ionization mass…

Projects

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Beam ionization: who gets the charge and why do some get broken up about it?

Iron, Ferroptosis and Ovarian Cancer

An EMSL User-ready spatially resolved metabolomics platform capable of high-lateral MS imaging and epifluorescence-based targeting

Soil-like habitats for spatial analysis of microbe-mineral interactions

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems