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Nancy Isern

Institution
Environmental Molecular Sciences Laboratory

Projects

Isolation of Isotopically-Labeled Nucleic Acids

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Exploratory Research
The primary goal of this project is to develop and implement new approaches for using isotopic labels in NMR-based DNA structure determination. 13C and 15N-labeled RNA and DNA will be isolated from…

Mass spectrometry analysis of nucleotides/nucleosides

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Exploratory Research
We wish to synthesize a number of specifically-labeled DNA oligomers that will be valuable in characterizing the structure and dynamics of damaged DNAs. In order to do this we will isolate 13C and…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Integrated Capability for Metabolomics and Fluxomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Nancy Washton
The goal of this project is to develop an integrated cyberinfrastructure that can be used to demonstrate a novel, end-to-end metabolomics and fluxomics use case: Isotopically Non-STationary…

Probing the pathology of pulmonary fibrosis using NMR metabolomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Nancy Isern
Pulmonary fibrosis is a relatively common condition affecting two-hundred thousand people in the US. The mean duration of survival from the time of diagnosis of idiopathic pulmonary fibrosis (IPF)…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Purity analyses of DNA

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Nancy Isern
Project type
Exploratory Research

Cell metabolism and c-Myc-induced growth, proliferation and neoplasia.

Lead Institution
Fred Hutchinson Cancer Research Center
Principal Investigator
Fionnuala Morrish
Project type
Capability Research
Chemical and radiological damage to cells can result in inactivation of tumor suppressors or activation of oncogenes, increasing the risk of cancer. The c-Myc oncogene (Myc) is deregulated in over 50…