Paul Piehowski

The National Microbiome Data Collaborative: improving metaproteomics methods and processing capabilities

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

We will improve and streamline the metaproteomics analysis workflow used by both EMSL and the NMDC. Generating gold-standard proteomics data will support algorithmic improvements for the inference of…

Development of an Environmental-Focused DIA Pipeline for HTP Proteomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Isaac Attah

Currently, metaproteomics workflows are hindered by sample complexity which necessitates fractionation of the sample meaning one sample can require 12 to 24 MS analyses. Data dependent workflows …

PNNL/Pfizer Project for the Development and Evaluation of Nanoproteomics Approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

PNNL has developed and continues to develop multiple approaches and analytical capabilities for nanoproteomics; to process and analyze via liquid chromatography mass spectrometry (LC-MS) samples on…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

PNNL/Pfizer Project for the Development and Evaluation of Nanoproteomics Approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

PNNL has developed and continues to develop multiple approaches and analytical capabilities for nanoproteomics; to process and analyze via liquid chromatography mass spectrometry (LC-MS) samples on…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

The National Microbiome Data Collaborative: improving metaproteomics methods and processing capabilities

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Lee Ann McCue

We will improve and streamline the metaproteomics analysis workflow used by both EMSL and the NMDC. Generating gold-standard proteomics data will support algorithmic improvements for the inference of…

Pathway Discovery, Validation and Compound Identification for Alzheimer's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vladislav Petyuk

The overall goal of the proposed study is the discovery and preclinical validation of novel targets associated with molecular processes that lead to cognitive decline, the primary outcome of most AD…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

PNNL/Pfizer Project for the Development and Evaluation of Nanoproteomics Approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

PNNL has developed and continues to develop multiple approaches and analytical capabilities for nanoproteomics; to process and analyze via liquid chromatography mass spectrometry (LC-MS) samples on…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

OHSU-PNNL Northwest Co-laboratory for Integrated Omics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

PTRC Proteogenomic Translational Research Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

Pathway Discovery, Validation and Compound Identification for Alzheimer's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vladislav Petyuk

The overall goal of the proposed study is the discovery and preclinical validation of novel targets associated with molecular processes that lead to cognitive decline, the primary outcome of most AD…

A scalable mass spectrometry platform for proteome mapping of brain tissues

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tujin Shi

The brain is the most complex organ in the mammalian body. Bulk analysis obscures heterogeneity of cell types present even in the smallest brain regions. Multi-omics single-cell resolution 3D…

Pathway Discovery, Validation and Compound Identification for Alzheimer's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vladislav Petyuk

The overall goal of the proposed study is the discovery and preclinical validation of novel targets associated with molecular processes that lead to cognitive decline, the primary outcome of most AD…

A paradigm shift for ovarian cancer biomarkers: Utilizing routine Pap tests as liquid biopsies for the development of targeted mass spectrometrybased
proteomic assays for early detection

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Ovarian cancer is the 5th leading cause of cancer deaths in women in the U.S. Earlier detection is the key to increased survival for women with ovarian cancer, yet a screening tool that is both…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

Metabolomic and Proteomic Composition of Human Tears using MPLEx and nanoproteomics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Background The Aicher lab has an NEI-funded grant (R61 EY032468) to identify protein biomarkers in human tears. Specifically, we will look at patients who have LASIK surgery and compare tear proteins…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Project type

Large-Scale EMSL Research

The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

PNNL/Pfizer Project for the Development and Evaluation of Nanoproteomics Approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

PNNL has developed and continues to develop multiple approaches and analytical capabilities for nanoproteomics; to process and analyze via liquid chromatography mass spectrometry (LC-MS) samples on…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Type 1 diabetes (T1D) is a complex autoimmune disease. Recent clinical studies show that pancreatic beta-cell dysfunction (e.g., a decline of first phase insulin release) occurs several years before…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Pathway Discovery, Validation and Compound Identification for Alzheimer's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vladislav Petyuk

The overall goal of the proposed study is the discovery and preclinical validation of novel targets associated with molecular processes that lead to cognitive decline, the primary outcome of most AD…