Robert Rittenhouse

Walla Walla University

Projects

The Molecular Basis for Polymerase-beta Fidelity During DNA Repair

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

T. Straatsma

Project type

Capability Research

Computational modeling studies of polymerase beta (pol b) will be carried out to provide novel insight into the role that protein dynamics plays in Pol b fidelity. If molecular dynamics were found to…

(gc11-2002)Biomolecular Simulation of Base Excision Repair and Protein Signaling

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

T. Straatsma

Project type

Capability Research

Environmental factors including ionizing radiation contribute to continuous damage of cellular DNA, in addition to endogenous sources. The damage resulting from oxidative stress and ionizing…