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Samuel Wilson

Institution
National Institute of Environmental Health Sciences, NIH

Projects

Investigation of the role of Mg2+ in DNA repair proteins APE1, Pol ?, and FEN1

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Capability Research
Nuclear DNA is continuously damaged by endogenous sources, such as the reactive free radicals produced during oxidative metabolism, or by exogenous sources, such as ionizing radiation. It has been…

Investigation of the role of Mg2+ in DNA repair proteins APE1, Pol ?, and FEN1

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Capability Research
Nuclear DNA is continuously damaged by endogenous sources, such as the reactive free radicals produced during oxidative metabolism, or by exogenous sources, such as ionizing radiation. It has been…

Investigation of the role of Mg2+ in DNA repair proteins APE1, Pol ?, and FEN1

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Capability Research
Nuclear DNA is continuously damaged by endogenous sources, such as the reactive free radicals produced during oxidative metabolism, or by exogenous sources, such as ionizing radiation. It has been…

Investigation of the role of Mg2+ in DNA repair proteins APE1, Pol ?, and FEN1

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Paul Ellis
Project type
Capability Research
We propose to utilize unique capabilities within the EMSL (low temperature solid-state NMR and the mpp2 super computer) to investigate Mg2+ binding to two DNA repair proteins Pol ? and APE1. In the…

Magnesium NMR of DNA Repair Proteins

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Exploratory Research
The chemistry central to the function of the DNA repair proteins apurinic/apyrimidic endonuclease 1 (APE1) and polymerase beta (pol beta) is the chemistry of water activated by a magnesium ion. …

Invesitgation of the role of Mg2+ in DNA repair proteins

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Capability Research
The chemistry central to the function of the DNA repair proteins APE1, Pol b and FEN1 is the chemistry of water activated by a magnesium ion. Further, Mg2+ also facilitates the organization of the…

Invesitgation of the role of Mg2+ in DNA repair proteins

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Andrew Lipton
Project type
Capability Research
The chemistry central to the function of the DNA repair proteins APE1, Pol b and FEN1 is the chemistry of water activated by a magnesium ion. Further, Mg2+ also facilitates the organization of the…