Si Wu | Environmental Molecular Sciences Laboratory

Translation repressor, 4E-BP2, is covalently modified in the mammalian brain.

Lead Institution

McGill University

Principal Investigator

Michael Bidinosti

Project type

Exploratory Research

This is an NCRR collaborative research project with the group of Dr. Richard Smith. The eIF4E-binding proteins (4E-BPs) are a family of three conserved polypeptides that inhibit translation by…

Integrating intact protein proteomics with ChIP-Seq for identification and functional characterization of epigenetic histone modifications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Large-Scale EMSL Research

Biological systems are exceedingly more complex than defined by the genome due to differential protein expression and degradation, altered mRNA splicing, and the presence of multiple post…

Systematic Characterization of Protein Glycosylation of Bacteria Cell Surface Proteins

Lead Institution

University of Oklahoma

Principal Investigator

Si Wu

The overall goal of this proposal is to develop an integrated top-down and bottom-up approach for bacterial glycoprotein profiling assisted by accurate glycan structure identification, which will be…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Secretomes from soil fungi in temperate forests and arid grasslands that are responsive to altered C and N deposition

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Cheryl Kuske

Project type

Large-Scale EMSL Research

Temperate ecosystems are experiencing increasing levels of atmospheric CO2 and nitrogen (N) deposition, which alter plant productivity and the amount and quality of above and belowground carbon. The…

Genome-enabled Investigations of the Role of Secreted Proteins and Reactive Metabolites in Carbon Degradation by Pure and Mixed Ascomycete Fungal Communities

Lead Institution

Woods Hole Oceanographic Institution

Principal Investigator

Colleen Hansel

Project type

FICUS Research

The Eumycete fungi (primarily Basidiomycota and Ascomycota) are key organisms in the degradation of wood, plant and animal material. While ascomycetes are less capable of rapid wood decay than…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Protein markers to type 1 diabetes progression

Lead Institution

University of North Carolina Greensboro

Principal Investigator

Qibin Zhang

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic ?-cells – a long asymptomatic period spanning many months to years. Currently, autoantibodies to islet cell…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Projects