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Si Wu

University of Oklahoma


An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution
Erasmus University Medical Center, Rotterdam
Principal Investigator
Theo Luider
Project type
Exploratory Research
We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Protein markers to type 1 diabetes progression

Lead Institution
University of North Carolina Greensboro
Principal Investigator
Qibin Zhang
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic ?-cells – a long asymptomatic period spanning many months to years. Currently, autoantibodies to islet cell…