Stephen Ragsdale

Exploring gas migration and diffusion pathways in CODH/ACS using molecular simulations

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

Project type

Large-Scale EMSL Research

In the coming decade, our planet is going to face several environmental and energy related problems which directly relate to the biological fixation of carbon dioxide CO2 into organic carbon which…

Computational Mechanistic Studies of Methyl-coenzyme M Reductase Enzyme

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Bojana Ginovska

Project type

Large-Scale EMSL Research

Methane is the second most abundant greenhouse gas after CO2, which accounts for 14% of global greenhouse gas emissions, and it is by far the largest constituent of natural gas deposits. Methyl…

NMR structure determination of the cobalamin binding protein HgcA and the ferredoxin-like protein HgcB required for bacterial mercury methylation

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Alexander Johs

Project type

Large-Scale EMSL Research

Mercury is a pervasive global pollutant. Its methylated form, methylmercury, poses a substantial threat to human health. Methylation of mercury (Hg) by anaerobic bacteria is the primary source of…

Identification of protein interaction networks, cofactors and protein structures essential for mercury methylation in anaerobic bacteria

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Alexander Johs

Project type

Large-Scale EMSL Research

Mercury is a pervasive global pollutant. Methylation of mercury (Hg) by anaerobic bacteria is the primary source of toxic methylmercury, which bioaccumulates up trophic levels and affects humans…

CO2 activation and conversion by the CODH/ACS enzymatic complex

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

Project type

Large-Scale EMSL Research

The purpose of the proposal is to computationally characterize the key biochemical and biophysical features of carbon monoxide dehydrogenase (CODH) and acetyl-coenzyme A synthase (ACS) enzymatic…

Projects

Exploring gas migration and diffusion pathways in CODH/ACS using molecular simulations

Computational Mechanistic Studies of Methyl-coenzyme M Reductase Enzyme

NMR structure determination of the cobalamin binding protein HgcA and the ferredoxin-like protein HgcB required for bacterial mercury methylation

Identification of protein interaction networks, cofactors and protein structures essential for mercury methylation in anaerobic bacteria

CO2 activation and conversion by the CODH/ACS enzymatic complex