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Thomas Metz

Institution
Pacific Northwest National Laboratory

Projects

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

Cyanobacteria Membrane Biology Grand Challenge: Systems Analysis of the Dynamics of Membrane Architecture, Composition, and Function- Proteomic, Metabolomic, and Metallomic Characterization

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Project type
Grand Challenge
The strain Cyanothece sp. ATCC 51142, isolated from benthic waters off the coast near Galveston, Texas, is a unicellular strain approximately 4-7 μm in diameter along the major axis. This…

Biological Systems Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
James Fredrickson
SPECIFIC AIMS: The overall objective of the proposed research is to acquire a predictive understanding of how microbial interactions impart stability, fitness, and functional efficiency to microbial…

Establishment of a Robust Method for Soil Metabolomics Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vanessa Bailey
Project type
Limited Scope
The objective of this work is to adapt current evolving protocols for metabolomics analyses to soil samples. As chemical perturbations are primarily detected on a molecular level, the metabolome will…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

LC-MS-based metabolomics for computational toxicology

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The goal of this project is to assist the Environmental Protection Agency in analyzing samples from a fish-model of environmental exposure. LC-MS-based metabolomics will be utilized to help develop…

Mapping soil carbon from cradle to grave: using comparative transcriptomics, proteomics and metabolite analysis to identify the microbial blueprint for root-enhanced decomposition of organic matter.

Lead Institution
University of California, Berkeley
Principal Investigator
Mary Firestone
Project type
FICUS Research
In this JGI-EMSL project, we will investigate how living roots impact the functional capacity of the detritosphere (litter and surrounding soil) microbiome that is actively mediating decomposition…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Kristin Burnum-Johnson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

A Systems Biology Approach to Emerging Respiratory Viral Diseases

Lead Institution
University of Washington
Principal Investigator
Michael Katze
This Systems Biology Program will comprehensively analyze and model the molecular and cellular events and pathogen-host interactions that occur during the course of respiratory virus infection. Our…

Integrated Capability for Metabolomics and Fluxomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Nancy Washton
The goal of this project is to develop an integrated cyberinfrastructure that can be used to demonstrate a novel, end-to-end metabolomics and fluxomics use case: Isotopically Non-STationary…

METABOLOMICS ANALYSES OF THE MICROBIOME FOR DEFENSE HEALTH

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
PNNL will perform both targeted and untargeted metabolomics analyses of human fecal samples to assess the role of diet and dietary components on host health.

Metabolomics analyses of the microbiome for defense health

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
PNNL will perform both targeted and untargeted metabolomics analyses of human fecal samples to assess the role of diet and dietary components on host health.

A Molecular Atlas of the Developing Lung

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

OHSU-PNNL Northwest Co-laboratory for Integrated Omics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Diagnosis of sub-clinical cryptic group A streptococcal myonecrosis

Lead Institution
Boise VA Medical Center
Principal Investigator
Amy Bryant
Invasive group A streptococcal (GAS) infections associated with shock, multi-organ failure, necrotizing fasciitis with myonecrosis, and death emerged worldwide in the mid-1980s prompting an official…

Enabling Agile Biomanufacturing with Leading Edge Analytical Biology

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Mark Butcher
This proposed EMSL User project supports a larger multi-lab "Agile Biomanufacturing" project (LBNL, PNNL, SNL). Through the EMSL’s leading edge analytical biology, GC and LC mass…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

Regulatory dynamics of microbial communities

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
H Wiley
Project type
Large-Scale EMSL Research
This is a proposal to conduct work in EMSL in support of the Foundational Scientific Focus Area (FSFA) research program at Pacific Northwest National Laboratory. This large-scale research program…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…