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Thomas Metz

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0001-6049-3968

Projects

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Effects of Silymarin on the Metabolome

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Silymarin (SM)-derived natural products interact with mammalian biomolecules in a specific and productive manner to cause changes in signal transduction and gene expression in a cell to protect the…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Reconstructing the Mycobacterium Tuberculosis Metabolic Model

Lead Institution
National Institute of Allergy and Infectious Diseases
Principal Investigator
Clifton Barry
Project type
Large-Scale EMSL Research
Tuberculosis (TB) kills 3 million people every year, and the rising tide of drug-resistant TB threatens to overwhelm global health programs. New and improved drugs are urgently needed to shorten the…

Protein markers to type 1 diabetes progression

Lead Institution
University of North Carolina Greensboro
Principal Investigator
Qibin Zhang
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic ?-cells – a long asymptomatic period spanning many months to years. Currently, autoantibodies to islet cell…

A Molecular Atlas of the Developing Lung

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Scott Baker
The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Predictive Modeling of Viral Pathogenesis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The interactions between a host and a pathogen are complex, representing a molecular interplay that results in either health or disease as an outcome. Understanding the nuances of these interactions…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

GC-MS Analysis of Alkaline Cellulose Degradation Products

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Cort
Project type
Exploratory Research
Degradation of cellulose and other polysaccharides in alkaline conditions and at elevated temperatures yields mixtures of compounds containing carboxylic acid and/or alcohol functional groups. These…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Scott Baker
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Project type
Exploratory Research
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

NMR-based metabolomics of the enteropathogens Salmonella and Yersinia

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Large-Scale EMSL Research
The goal of this research is to analyze and reconstruct intercellular and intracellular networks in Salmonella and Yersinia using multiple types of -omics data. Although we hope to gain a more…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Identification of Metabolite Toxins

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
This project will collect data on ion-mobility, accurate mass and compound fragmentation data using an ESI-IMS-MS/MS system for a number of metabolite toxins and structurally similar compounds. This…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Advanced Proteomics and Metabolomics Studies of Type 1 Diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
In this four year two phase (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometry technologies…

Deciphering Microbial Communication Through Metabolites

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This project will establish a Metabolomics Center at PNNL that will develop the advanced measurement capabilities necessary to define the metabolic processes of microbiomes and determine how these…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Development of Metabolomics for Biomarker Discovery

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
Project type
Exploratory Research
Metabolomics is a holistic approach to the study of a biological system’s metabolite complement (often generalized to include essentially all small molecules), and its practice is anticipated to…

A Systems Biology Approach to Emerging Respiratory Viral Diseases

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This Systems Biology Program will comprehensively analyze and model the molecular and cellular events and pathogen-host interactions that occur during the course of respiratory virus infection. Our…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…