Thomas Metz

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

FSFA: MOSAIC -- Metabolic and Spatial Interactions in Communities FY18 proposal

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Errol Robinson

This EMSL user proposal is to support the MOSAIC DOE BER funded FSFA at PNNL. The primary activities involving EMSL are a set of BSSD demonstration tasks focusing on key science questions and related…

Mapping Nutrient Flow through a Plant-Microbe Symbiont System using Stable Isotope Probing under Drought and Salinity Stress

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kim Hixson

Red alder (Alnus rubra) is one of the fastest growing, commercially important, hardwood species for biomass/timber production in North America, and is also involved in a nitrogen-fixation symbiosis…

Does the brain differentially alter metabolic and immunologic programs in the bone marrow in a pathogen-specific manner?

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Sneha Couvillion

: A wide variety of pathogens present an acute survival challenge in humans, and our ability to rapidly and precisely respond to these pathogens is critical to our survival as a species. Although…

High Resolution 1H NMR Metabolomics Using Slow and Ultra Slow Magic Angle Spinning

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

Recently, we developed new so-called slow-MAS (magic angle spinning) NMR techniques that significantly enhance the spectral information in biofluids, intact excised tissues, organs and live small…

Biological Systems Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Fredrickson

SPECIFIC AIMS: The overall objective of the proposed research is to acquire a predictive understanding of how microbial interactions impart stability, fitness, and functional efficiency to microbial…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Establishment of a Robust Method for Soil Metabolomics Analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vanessa Bailey

Project type

Limited Scope

The objective of this work is to adapt current evolving protocols for metabolomics analyses to soil samples. As chemical perturbations are primarily detected on a molecular level, the metabolome will…

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

Type 1 diabetes (T1D) is generally accepted to result from impaired immune tolerance, leading to the autoimmune destruction of islet beta cells. However, the durable preservation of beta cell…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Prediction of response in soil microbiome carbon utilization to changing moisture conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jason McDermott

This project is directed under the “Phenotypic Response of the Soil Microbiome to Environmental Perturbations” SFA project awarded to Pacific Northwest National Laboratory. The goal of the SFA is to…

EMSL Science Overview

Thomas Metz

Projects

Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

FSFA: MOSAIC -- Metabolic and Spatial Interactions in Communities FY18 proposal

Mapping Nutrient Flow through a Plant-Microbe Symbiont System using Stable Isotope Probing under Drought and Salinity Stress

Does the brain differentially alter metabolic and immunologic programs in the bone marrow in a pathogen-specific manner?

High Resolution 1H NMR Metabolomics Using Slow and Ultra Slow Magic Angle Spinning

Biological Systems Interactions

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Establishment of a Robust Method for Soil Metabolomics Analysis

BetaMarker: Biomarkers of Beta Cell Stress in Type 1 Diabetes

Pacific Northwest Advanced Compound Identification Core

Prediction of response in soil microbiome carbon utilization to changing moisture conditions