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Weijun Qian

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-5393-2827

Projects

Multiplex Mass Spectrometric Protein Assays for Obesity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
The prevalence of overweight and obesity has increased dramatically in recent decades in both children and adults, reaching an epidemic proportion. In order to gain new insights into the…

Global and Targeted Proteomic Identification of oxidative modifications.

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Diana Bigelow
Project type
Exploratory Research
Recent research has provided an emerging picture of the significant role of reactive oxygen/nitrogen species (ROS/RNS) and their associated modification of cellular proteins in cellular signaling…

Multiplex Mass Spectrometric Protein Assays for Obesity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
The prevalence of overweight and obesity has increased dramatically in recent decades in both children and adults, reaching an epidemic proportion. In order to gain new insights into the…

Technology development in support of NCRR

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Nancy Colton
The Pacific Northwest National Laboratory (PNNL) has built a facility that already stands at the forefront of proteomic research. Moreover, the Center is uniquely poised for future developments. We…

Urinary Proteome Monitoring for Transplant Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
We propose to achieve the objective of identifying novel urinary biomarkers for selected categories of renal transplant injury in two phases. We will first employ a discovery phase to comprehensively…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

Validation and Advanced Development of Emerging Technologies

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Keqi Tang
Develop mass spectrometry (MS) based assays for quantitative biomarker validation with sensitivity and specifically comparable to or better than antibody based immunoassays. The new liquid…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Kristin Burnum-Johnson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Discovery novel therapeutic protein targets by advanced MS proteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
The objective of this research is to discover novel therapeutic protein targets for human metabolic diseases by applying advanced PNNL proteomics technologies to a variety of tissue, cell, or…

Proteomic Studies of type 2 diabetes using knockout mouse models

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
This is an NIH-funded R01 project on diabetes research. A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or beta-cells for replacement…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Multi-omic 3D tissue maps for a Human BioMolecular Atlas

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Spatially resolved molecular maps of mammalian organs hold significant promise in providing a deeper under-standing of human organ functioning in health and disease states. Fundamental to this is an…

Proteomic comparison of lyophilized and fresh human plasma

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Project type
Limited Scope
This is a DOE-funded technology assistance by applying MS-based proteomics to assess the feasibility of comparing the differences between lyophilized and fresh-frozen plasma. The assistance is…

Serum biomarkers for predicting type 1 diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Clinical type 1 diabetes (T1D) is preceded by an asymptomatic phase of the disease, which can be readily identified by serum islet autoantibodies(AAb). However, the T1D field is challenged by the…

Multi-marker Urine Test for Detection of Aggressive Prostate Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
In prostate cancer disease management over-diagnosis and over-treatment have increasingly become major public concerns. Prostate cancer is primarily detected by serum PSA screening followed by a…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Structural profiling of the molecular interactome to define phenotype

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Melchior
The functional pathways that define phenotype are reflected by protein quinary structure; the transient encounters of proteins with other proteins, molecules, cofactors, and nucleic acids that…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

Proteomic Studies of type 2 diabetes using knockout models

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or beta-cells for replacement therapy. Therefore, a fundamental knowledge of mechanisms and…

Cancer Moonshot - Framingham

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The purpose of the Cancer Moonshot -Framingham project is to apply multiplex quantitative LC-SRM-MS assays for comprehensive, quantitative analysis of longitudinal serum samples associated with head…