Skip to main content

William Chrisler

Institution
Pacific Northwest National Laboratory

Projects

In situ mesoscale imaging of biofilm dynamics using SALVI

Lead Institution
Oak Ridge National Laboratory
Principal Investigator
Xiao-Ying Yu
Understanding how metabolic pathways are interconnected and controlled at the subcellular scale within living systems with coexisting macromolecules in a cell that has complex structure, dynamics,…

A Molecular Atlas of the Developing Lung

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Deep UV laser ablation system for spatial single-cell proteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
William Chrisler
Laser capture microdissection (LCM) is the key capability for spatially resolved omicss. However, commercially available LCM systems are designed for mammalian tissues and feature UV lasers (330 nm),…

The Lignin Enigma: Turning the Corner

Lead Institution
Washington State University
Principal Investigator
Norman Lewis
Project type
Large-Scale EMSL Research
Lignins (Nature's second most abundant terrestrial plant substances) provide structural support for plants to stand upright, to conduct water/nutrients, and as barriers to opportunistic…

A streamlined platform for phosphoproteome mapping of human tissues

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tujin Shi
Recent technological advances in genomics, transcriptomics, and proteomics allow for rapid generation of comprehensive 3D-human tissue maps for biomolecules DNAs, RNAs, and proteins at the single…

PhenoAccess: Physiological Phenotyping of Brachypodium Accessions

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Amir Ahkami
Although the effects of elevated CO2 on plant growth, physiology and metabolism has been investigated thoroughly, the underlying integrated organismal, cellular and molecular mechanisms of these…

InterCom

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christer Jansson
We intend to identify how molecular interactions at the intercellular level participate in controlling carbon assimilation, allocation and transformation in the plant-microbe-soil system (Fig. 1),…

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Erin Bredeweg
The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics/metabolomics to establish baseline cell biological and metabolite data on DNA agility in eukaryotic organisms, and…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Corley
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…