Yehia Ibrahim

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

High Resolution High Throughput Proteomics Platform for Cancer Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

The objective of this project is to develop and evaluate a new high-throughput and ultra-sensitive platform that will enable more effective and higher throughput proteomics measurements to support…

High Resolution High Throughput Proteomics Platform for Cancer Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

The objective of this project is to develop and evaluate a new high-throughput and ultra-sensitive platform that will enable more effective and higher throughput proteomics measurements to support…

Identification of Metabolite Toxins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Wunschel

This project will collect data on ion-mobility, accurate mass and compound fragmentation data using an ESI-IMS-MS/MS system for a number of metabolite toxins and structurally similar compounds. This…

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The ability to capture and visualize the complex metabolic behavior of living organisms in situ is a bioanalytical grand challenge that has yet to be fully realized. Ambient ionization mass…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Development of High Throughput Proteomic Production Operations (PNNL Scope # 40601, Dick Smith's OBER Proteomics)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Nancy Colton

This project is developing the capability for high throughput and quantitative measurements of microbial proteomes along with the informatics capabilities necessary to support such applications. Some…

High Resolution High Throughput Proteomics Platform for Cancer Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

The objective of this project is to develop and evaluate a new high-throughput and ultra-sensitive platform that will enable more effective and higher throughput proteomics measurements to support…

Development of an Ultra-High Throughput and Highly Sensitive Proteomics Instrumental Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Project type

Scientific Partner

This project will develop and initially demonstrate a powerful new "next generation" instrumental platform for ultra-high throughput proteomics that will enable a range of new measurement…

Resolution of Lipid Structural Diversity for Threat-Agnostic Signature Development

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jennifer Kyle

Development of threat-agnostic biosignatures is critical for detection of and response to biological threats that go beyond the historical list-based approach. Lipids are a class of structurally…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Projects