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Ying Zhu

Institution
Environmental Molecular Sciences Laboratory
ORCID
ORCID logo 0000-0002-5416-0566

Projects

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

The Lignin Enigma: Turning the Corner

Lead Institution
Washington State University
Principal Investigator
Norman Lewis
Project type
Large-Scale EMSL Research
Lignins (Nature's second most abundant terrestrial plant substances) provide structural support for plants to stand upright, to conduct water/nutrients, and as barriers to opportunistic…

Integrated multi-omics analysis of multiple myeloma

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
In this project, integrated quantitative global proteomics and phosphoproteomics analysis of multiple myeloma cases (unsorted and sorted cell types) will be performed using multiplexed tandem mass…

Characterizing the ecophysiologies of uncultured syntrophic associations driving anaerobic methane oxidation: applications of targeted meta'omics and multi-modal analytical imaging of diverse archaeal-bacterial consortia

Lead Institution
California Institute of Technology
Principal Investigator
Victoria Orphan
Project type
FICUS Research
The main objective of this work is to combine the molecular, elemental and cryo-electron imaging and metaproteomics available at EMSL with the single cell genomics pipeline at the JGI in a highly…

High throughput and in-depth single-cell proteomics for plant cells

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ying Zhu
In support of the "Single-cell biology" value stream in EMSD/EMSL DigiPhen Motivation, we propose to develop a high throughput and in-depth single-cell proteomics platform. We aim to…

PhenoAccess: Physiological Phenotyping of Brachypodium Accessions

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Amir Ahkami
Although the effects of elevated CO2 on plant growth, physiology and metabolism has been investigated thoroughly, the underlying integrated organismal, cellular and molecular mechanisms of these…

Integrated single-cell transcriptomics and proteomics platform

Lead Institution
Scienion
Principal Investigator
Joshua Cantlon-Bruce
Project type
Scientific Partner
In this partner project, Scienion and EMSL teams will work together to develop an integrated single-cell transcriptomics and proteomics platform. The platform will enable us to simultaneously profile…

Joining Systems Biology and Bioimaging on Same Cells

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
We plan to develop a new capability at EMSL for coupling bioimaging and systems biology analysis of the same exact cells. The use of the highly simplified and smallest free-living eukaryote…

Deep UV laser ablation system for spatial single-cell proteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
William Chrisler
Laser capture microdissection (LCM) is the key capability for spatially resolved omicss. However, commercially available LCM systems are designed for mammalian tissues and feature UV lasers (330 nm),…

Multi-omic 3D tissue maps for a Human BioMolecular Atlas

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Spatially resolved molecular maps of mammalian organs hold significant promise in providing a deeper under-standing of human organ functioning in health and disease states. Fundamental to this is an…